Results 71 to 80 of about 4,057,470 (304)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

OH airglow imaging observations of a mesoscale gravity wave generated by jet streams near the Tibetan Plateau region

Earth and Planetary Physics
In this study, we investigate the source and dynamics of a mesoscale gravity wave (MGW) observed over northern China. On January 12, 2010, an OH airglow imager at the Xinglong station (40.2°N, 117.4°E) detected an MGW propagating from southwest to ...
QinZeng Li, YiLin Liu, JiYao Xu, Wei Yuan, YaYun Zhu, Xiao Liu   +5 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Observations of the Magnetopause Reconnection Ion Diffusion Region With High‐Density O+ Ions During the May 2024 Superstorm

Geophysical Research Letters
Based on high‐resolution measurements from NASA's Magnetospheric Multiscale mission (MMS), we present the first direct observation of an ion diffusion region (IDR) with high number density O+ ions within dayside magnetopause reconnection during the May ...
Anxin Zhang, Suping Duan, Lei Dai, Yuntian Hou, Yong Ren, Chi Wang, S. A. Fuselier, C. Philippe Escoubet, James L. Burch   +8 more
doaj   +1 more source

IASM: Individualized activity space modeler

SoftwareX, 2018
Researchers from various disciplines have long been interested in analyzing and describing human mobility patterns. Activity space (AS), defined as an area encapsulating daily human mobility and activities, has been at the center of this interest. However, given the applied nature of research in this field and the complexity that advanced geographical ...
openaire   +4 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The macroeconomic spillovers from space activity. [PDF]

Proc Natl Acad Sci U S A, 2023
Corrado L, Grassi S, Paolillo A, Silgado-Gómez E.   +3 more
europepmc   +1 more source

Learning Activity Spaces: Towards Flexibility in Learning Design?

2009 Ninth IEEE International Conference on Advanced Learning Technologies, 2009
Designing a computer-supported learning scenario involving a constructivist approach of learning lays on a paradox. On the one hand, learning flows must be precisely described - including role distribution, required resources, tools, and scaffolds - to be realized in computer-supported environments.
Lejeune, Anne, Ney, Muriel, Weinberger, Armin, Pedastre, Margus, Bollen, Lars, Hovardas, Tasos, Hoppe, Ulrich, de Jong, Ton   +7 more
openaire   +3 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Differences in Life Space Activity Patterns Between Older Adults With Mild Cognitive Impairment Living Alone or as a Couple: Cohort Study Using Passive Activity Sensing. [PDF]

JMIR Aging, 2023
Muurling M, Au-Yeung WM, Beattie Z, Wu CY, Dodge H, Rodrigues NK, Gothard S, Silbert LC, Barnes LL, Steele JS, Kaye J.   +10 more
europepmc   +1 more source