Results 61 to 70 of about 10,477,825 (292)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

ISNet: Decomposed Dynamic Spatio‐Temporal Neural Network for Ionospheric Scintillation Forecasts

Space Weather
Accurate prediction of ionospheric scintillation is essential for ensuring the reliability of spaceborne and ground‐based radio wave technology infrastructures, including but not limited to navigation and communication systems.
Zhixu Gao, Yanhong Chen, Xianzhi Ao, Fulu Yue, Hong Chen, Hao Deng, Bingxian Luo, Xin Wang, Tianjiao Yuan   +8 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

SWIFF : space weather integrated forecasting framework [PDF]

, 2013
This research has received funding from the European Commission’s FP7 Program with the grant agreement SWIFF (Project No. 2633430, swiff.eu). The KU Leuven simulations were conducted on the computational resources provided by the PRACE Tier-0 Project No.
Viviane Pierrard, Bemporad, Alessandro, Parnell, Clare Elizabeth, O. Sebek, HENRI, PIERRE REMI ANTOINE, Mackay, Duncan H., Ondřej Šebek, Clare E. Parnell, Nordlund, Åke, Trávníček, Pavel M., Bemporad, A., Åke Nordlund, Mackay, Duncan Hendry, R. Keppens, A. Restante, Alessandro Bemporad, Pegoraro, Francesco, Parnell, C., V. Pierrard, Pierrard, Viviane, Markidis, Stefano,, D. Mackay, Keppens, R., Restante, A., Mackay, D., Faganello, Matteo, Stefano Markidis, Jacob Trier Frederiksen, Mackay, D.H., A. Bemporad, Faganello, M., Rony Keppens, Kris Borremans, Olshevsky, Vyacheslav, Pegoraro, F., Susino, R., M. Faganello V. Olshevsky, Parnell, Clare E., Borremans, K., K. Borremans, S. Poedts, Parnell, C.E., C. Parnell, Frederiksen, J., Lapenta, G., Califano, Francesco, S. Markidis, Francesco Califano, Restante, A.L., Borremans, Kris, Giovanni Lapenta, Pierrard, V., Keppens, Rony, Šebek, Ondřej, Trier Frederiksen, Jacob, Susino, Roberto, Lapenta, Giovanni, Henri, P., Califano, F., J. Frederiksen, Pavel M. Trávníček, Travnıcek, P., Pierre Henri, Restante, Anna Lisa, Markidis, S., Henri, Pierre, Stefaan Poedts, Vyacheslav Olshevsky, Markidis, Stefano, Duncan H. Mackay, Poedts, S., R. Susino, Frederiksen, Jacob Trier, Nordlund, A., G. Lapenta, Sebek, O., Anna Lisa Restante, Trávníček, P.M., Roberto Susino, Poedts, Stefaan, Olshevsky, V., A. Nordlund, Matteo Faganello, Francesco Pegoraro, Trávníček, Pavel M   +84 more
core   +1 more source

Observations of the Magnetopause Reconnection Ion Diffusion Region With High‐Density O+ Ions During the May 2024 Superstorm

Geophysical Research Letters
Based on high‐resolution measurements from NASA's Magnetospheric Multiscale mission (MMS), we present the first direct observation of an ion diffusion region (IDR) with high number density O+ ions within dayside magnetopause reconnection during the May ...
Anxin Zhang, Suping Duan, Lei Dai, Yuntian Hou, Yong Ren, Chi Wang, S. A. Fuselier, C. Philippe Escoubet, James L. Burch   +8 more
doaj   +1 more source

A nominally confined X6.4 flare associated with an extremely faint coronal mass ejection

Astronomy & Astrophysics
Context. The observational distinction between eruptive and confined solar flares is often based on whether a coronal mass ejection (CME) can be identified in coronagraph data.
Lin Wei, Zhou Guiping, Hou Yijun, Gao Changliang, Zhang Xiaofan, Wang Jingxiu   +5 more
doaj   +1 more source

The macroeconomic spillovers from space activity. [PDF]

Proc Natl Acad Sci U S A, 2023
Corrado L, Grassi S, Paolillo A, Silgado-Gómez E.   +3 more
europepmc   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Strong Longitudinal and Latitudinal Differences of Ionospheric Responses in North American and European Sectors During the 10–11 October 2024 Geomagnetic Storm

Remote Sensing
This study examines the spatiotemporal evolution of midlatitude ionospheric disturbances during the intense geomagnetic storm on 10–11 October 2024, focusing on the North American and European sectors.
Xinyue Luo, Ercha Aa, Xin Wang, Bingxian Luo   +3 more
doaj   +1 more source