Results 81 to 90 of about 1,126,883 (314)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Locating the place and meaning of physical activity in the lives of young people from low-income, lone-parent families [PDF]
, 2012 Background: In the United Kingdom (UK), it is predicted that economic cuts and a subsequent increase in child poverty will affect those already on the lowest incomes and, in particular, those living in lone-parent families.
Dagkas, S. +7 more
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Space WeatherThe polarity inversion line (PIL) in active regions (ARs) is considered to be closely associated with solar flare eruptions. In this study, we rigorously constructed standardized data sets based on time series of different lengths using Space‐weather HMI
Siwei Liu +7 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
European Space Lidar Activities.
The Review of Laser Engineering, 1995 Active laser remote sensing from space is recognised to be one of the most promising newmeans of obtaining essential atmospheric parameters on a global scale. This report gives anoverview on the ESA activities and will focus in the second part on the ongoing Doppler lidarsdevelopment at the German Aerospace Research Establishment (DLR).
openaire +3 more sources
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Frontiers in Astronomy and Space SciencesIntroductionGeomagnetically induced currents (GICs) pose a critical space weather hazard to ground-based conductive infrastructure. Previous studies have commonly identified large GIC events using daily maximum amplitudes exceeding 10 A, a criterion that
Wenjin Zhao +8 more
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Long-Term Variations in Background Bias and Magnetic Field Noise in HSOS/SMFT Observations
UniverseThe Solar Magnetic Field Telescope (SMFT) at Huairou Solar Observing Station (HSOS) has conducted continuous observations of solar vector magnetic fields for nearly four decades, and while the primary optical system remains unchanged, critical components—
Haiqing Xu +7 more
doaj +1 more source