Results 111 to 120 of about 4,042,448 (357)

Continuous space representations of human activity spaces

, 2005
Arbeitsberichte Verkehrs- und Raumplanung ...
Vaze, Vikrant S., Schönfelder, Stefan, Axhausen, Kay W.; id_orcid0000-0003-3331-1318   +2 more
openaire   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

The intravehicular activity space suit Final report, 5 Aug. 1968 - 1 Feb. 1970 [PDF]

Design and testing of intravehicular activity space ...
Friedman, D.
core   +1 more source

Spaces seeking activities - activities seeking spaces: Evaluation and policy design of neighbourhood-wide urban community spaces

City, Culture and Society
Cities thrive on the vibrant interplay of community-driven initiatives and the adaptive reuse of public spaces that foster socio-cultural activities, enriching civic life. However, these grassroots efforts often confront challenges such as spatial inadequacies caused by bureaucratic zoning policies and the scarcity of affordable real estate.
Blečić, Ivan, Cois, Ester, Muroni, Emanuel, Saiu, Valeria   +3 more
openaire   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Spacecraft architecture [PDF]

Three requirements for a spacecraft interior are considered. Adequate motor activity in the anatomical-physiological sense results from attention to the anthropometric characteristics of humans.
Zefeld, V. V.
core   +1 more source

SOLAR ERUPTION ON 4 JANUARY 2011: CASE STUDY FOR SPACE EARLY WARNING [PDF]

, 2011
We perform intuitive analysis for solar eruption on 4 January 2011. Since we do not have magnetic observational data from the eruption, we perform first order calculation and expands it as interplanetary total effect of energy propagation by retro ...
Bambang, Setiahadi
core  

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

The Connection between 3.3 {\mu}m PAH Emission and AGN Activity

, 2012
We investigate the connection between starburst and AGN activity by comparing the 3.3 {\mu}m PAH eimission with AGN properties. Utilizing the slit-less spectroscopic capability of the AKARI space telescope, we observe moderate-luminosity Type I AGN at z ...
Ballantyne, Bennert, Bennert, Bentz, Bentz, Ciotti, Clavel, Dawoo Park, Ferrarese, Galliano, Gebhardt, Greene, Gültekin, Ho, Hopkins, Hopkins, Imanishi, Imanishi, Imanishi, Imanishi, Imanishi, Ji Hoon Kim, Jong-Hak Woo, Kawakatu, Laurent, Lutz, Lutz, Masatoshi Imanishi, Merloni, Netzer, Ogle, Ohyama, Oi, Onaka, Park, Peterson, Robertson, Ryan, Sales, Schweitzer, Shang, Shi, Shi, Smith, Szathmary, Treu, Watabe, Woo, Woo, Woo, Woo   +50 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source