Results 151 to 160 of about 4,042,448 (357)

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

open access: yesMolecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

A Grid-constrained Fourier Neural Operator for Magnetic Field Extrapolation of the Solar Corona

open access: yesThe Astrophysical Journal
In this study, we propose a hybrid architecture for coronal magnetic field extrapolation modeling. This architecture integrates Fourier neural operators (FNOs) with grid-based finite-difference methods used to impose physical constraints and is named ...
Hao Yang   +5 more
doaj   +1 more source

Radio Detection of UHE Cosmic Rays and Neutrinos off the Moon with Two 30 m Telescopes

open access: yesUniverse
Due to the Askaryan effect, radio emissions will be produced when ultra-high-energy (UHE) cosmic rays and neutrinos impact the lunar regolith. Many experiments have been proposed and performed to detect such radio emissions from the lunar regolith ...
Linjie Chen   +3 more
doaj   +1 more source

Scheduling Markovian PERT networks with maximum-NPV objective. [PDF]

open access: yes
We examine project scheduling with net-present-value objective and exponential activity durations, using a continuous-time Markov decision chain. Based on a judicious partitioning of the state space, we achieve a significant performance improvement ...
Creemers, Stefan   +2 more
core  

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

open access: yesFEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

open access: yesFEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan   +6 more
wiley   +1 more source

Unveiling the Mixing and Transport Processes of Solar Wind and Planetary Ions in the Magnetopause Boundary Layer

open access: yesThe Astrophysical Journal
Kelvin–Helmholtz (KH) vortices are widely observed in astrophysics and heliophysics, including at Jovian and terrestrial magnetopauses, the Martian sheath–ionosphere boundary, the heliopause, and within stellar accretion disks.
Zhongwei Yang   +7 more
doaj   +1 more source

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