Results 61 to 70 of about 986,496 (318)

Review of recent observations of magnetic holes in the solar wind

open access: yesDiscover Space
Magnetic holes (MHs) are ubiquitous coherent structures within the solar wind, defined by localized depressions in the magnetic field. They are increasingly recognized as fundamental sites of energy conversion and particle energization, playing a crucial
C. Y. Li   +10 more
doaj   +1 more source

Differences in Life Space Activity Patterns Between Older Adults With Mild Cognitive Impairment Living Alone or as a Couple: Cohort Study Using Passive Activity Sensing. [PDF]

open access: yesJMIR Aging, 2023
Muurling M   +10 more
europepmc   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

The disrupted jet stream and its influence on flight time during solar proton events

open access: yesScientific Reports
The long-chain effects of eruptive solar activities on Earth’s magnetosphere, ionosphere, and the mid-to-lower atmospheric circulation are an important theoretical research topic in the fields of space weather and atmospheric science.
Xiaoheng Xu   +17 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

Mathematical expressions of the drag-based models for predicting the arrival time of coronal mass ejection and their development and evolutionary processes

open access: yesFrontiers in Astronomy and Space Sciences
As one of the most violent solar activities, coronal mass ejections (CMEs) are eruptions of the large-scale magnetized plasma from the Sun’s upper atmosphere into interplanetary space.
Xinhua Zhao   +12 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Comparative Study of the Single‐Event Functional Interrupt (SEFI) Rate in Solid‐State Drives (SSD) Through Ground and On‐Orbit Testing

open access: yesSpace Weather
Space radiation poses a significant threat to the reliability of spacecraft equipment, while traditional static space environment models exhibit substantial inaccuracies in calculating on‐orbit error rates. This study investigates single‐event functional
Yingqi Ma   +12 more
doaj   +1 more source

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