Results 51 to 60 of about 413,850 (313)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Ephemeral Religious Architecture—The Visits of the Pope to Madrid
ReligionsOn the occasion of mass religious events, liturgical ceremonies leave the temple and occupy public space. That is the case of the visits of the Pope or World Youth Days. How does architecture approach the ephemeral construction of this space?
Ignacio Vicens Hualde +2 more
doaj +1 more source
Elkawnie: Journal of Islamic Science and Technology, 2019 The mosque is a Muslim worship building that is commonly found in Muslim-populated areas. As the main building in Islam, with its significant role, it is relevant if the mosque building applies Islamic concepts in its spatial arrangement and circulation.
Nurul Fakriah
doaj +1 more source
Traceur as Bricoleur. Poaching public space through bricolent use of architecture and the body
, 2017 <p>This paper emerged from many months of regular participation in the parkour community in Indianapolis, Indiana. First, this study looks at the art of parkour as a bricolent engagement with architecture.
Matthew D. Lamb
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Frontiers in Soil ScienceUrban forests constitute vital ecological interfaces between built environments and natural systems, yet the mechanisms driving soil microbial community assembly in these ecosystems remain poorly understood.
Yi Zheng +10 more
doaj +1 more source
Recursive space: play and creating space [PDF]
, 2012 Space is reconfigured through the participations of both gamers and the game, where game is understood as the programming and hardware of a game technology.
Aylish Wood, Wood, Aylish
core +1 more source
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
Robot Action Space of Tractable Subsumption Architecture [PDF]
International Journal of Industrial Electronics, Control and Optimization, 2019 —In this article, a new hybrid feedback system is introduced, which integrates the behavior- based planning by reactive agent-based control scheme through subsumption architecture. At first, subsumption protocol studies the interactions of robot with its
farnaz sabahi
doaj +1 more source