Results 91 to 100 of about 11,957,490 (337)

Space-efficient Basic Graph Algorithms

, 2015
We reconsider basic algorithmic graph problems in a setting where an n-vertex input graph is read-only and the computation must take place in a working memory of O(n) bits or little more than that. For computing connected components and performing breadth-first search, we match the running times of standard algorithms that have no memory restrictions ...
Elmasry, Amr, Hagerup, Torben, Kammer, Frank   +2 more
openaire   +3 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The space exploration initiative. Operational efficiency panel space-basing technology requirements [PDF]

The topics covered include the following: (1) space basing technology requirements sources; (2) orbit transfer vehicle (OTV) processing heritage; (3) ground processing progression to space processing; (4) technology requirements for space based OTV ...
Pena, Luis R.
core   +1 more source

Improving fiscal space for health from the perspective of efficiency in low- and middle-income countries: What is the evidence?

Journal of Global Health, 2020
Background Conceptual frameworks of fiscal space for health have traditionally considered health system efficiency improvements as a means to free up resources for the sector. However, there has been no comprehensive review of the evidence to confirm the
W. Zeng, Yao Yao, Hélène Barroy, J. Cylus, Guohong Li   +4 more
semanticscholar   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

High-efficiency, radiation-resistant GaAs space cells [PDF]

Although many GaAs solar cells are intended for space applicatons, few measurements of cell degradation after radiation are available, particularly for cells with efficiencies exceeding 20 percent (one-sun, AMO).
Bertness, K. A., Grounner, M., Kuryla, M. S., Ristow, M. Ladle, Werthen, J. G.   +4 more
core   +1 more source

Atom-molecule conversion with particle losses

, 2011
Based on the mean-field approximation and the phase space analysis, we study the dynamics of an atom-molecule conversion system subject to particle loss.
B. Cui, C. W. Gardiner, L. C. Wang, S. H. Strogatz, W. E. Boyce, X. X. Yi   +5 more
core   +1 more source

Space-Efficient FPT Algorithms

, 2021
We prove algorithmic results showing that a number of natural parameterized problems are in the restricted-space parameterized classes Para-L and FPT+XL. The first class comprises problems solvable in f(k) n^{O(1)} time using g(k) + O(log n)) bits of space (k is the parameter and n is the input size; f and g are computable functions).
Biswas, Arindam, Raman, Venkatesh, Satti, Srinivasa Rao, Saurabh, Saket   +3 more
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Analyzing space efficiency in Japanese tall buildings

Journal of Asian Architecture and Building Engineering
Space efficiency in Japanese tall buildings holds substantial significance, shaped by financial, societal, and environmental imperatives. Nevertheless, comprehensive studies addressing spatial efficiency in such towers remain scarce.
Hüseyin Emre Ilgın, Özlem Nur Aslantamer   +1 more
doaj   +1 more source