Results 81 to 90 of about 2,813,854 (249)

Characteristics of deformation and defect of shield tunnel in coastal structured soil in China

Underground Space
Shield tunnel is a type of linear underground structure assembled by lining segments, characterized with long joint, weak stiffness, and strict deformation control requirement. The situation of the long-term deformation and defect of the shield tunnel in
Fanyan Meng, Bo Hu, Renpeng Chen, Hongzhan Cheng, Huaina Wu   +4 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Real-time surface settlement prediction in shield tunneling using a time-series framework and interpretable machine learning

Results in Engineering
: Current data-driven methods for surface settlement prediction in shield tunneling typically focus on static maximum values, often neglecting the cumulative influence of the continuous excavation process and the dynamic ground response. To address this,
Nie Zou, Hong-Zhan Cheng, Tian Dai, Zi-Han Yang   +3 more
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Summary of GaAs Solar Cell Performance and Radiation Damage Workshop [PDF]

The workshop considered the GaAs solar cell capability and promise in several steps: (1) maximum efficiency; (2) space application; (3) major technology problems (AR coating optimization, contacts); (4) radiation resistance; (5) cost and availability ...
Kamath, G. S.
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Beyond the reporting of disturbed areas: the use of Deter to analyze the spatiotemporal patterns of forest degradation in the Amazon

Geoscience Letters
The Brazilian Amazon, a critical component of Earth’s climate regulation and biodiversity, has been increasingly affected by forest degradation, a process less monitored than deforestation.
Walter Leal Filho, Fabio Corrêa Alves, Mariane Souza Reis, Vagner Luis Camilotti, Cassiano Gustavo Messias, José B. S. O. de A. Guerra   +5 more
doaj   +1 more source

Potential high efficiency solar cells: Applications from space photovoltaic research [PDF]

NASA involvement in photovoltaic energy conversion research development and applications spans over two decades of continuous progress. Solar cell research and development programs conducted by the Lewis Research Center's Photovoltaic Branch have ...
Flood, D. J.
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source