Results 61 to 70 of about 555,969 (265)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Space-Efficient Substring Occurrence Estimation

Algorithmica, 2011
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Orlandi, Alessio, VENTURINI, ROSSANO
openaire   +4 more sources

Space Efficiency of Transit-Oriented Station Areas: A Case Study from a Complex Adaptive System Perspective

ISPRS International Journal of Geo-Information
Transit-oriented development (TOD) has been widely adopted in urban planning to alleviate traffic congestion, urban sprawl, and other problems. The TOD metro station area, as a dynamic and open spatial system, presents typical complex features.
Jinwen Fan, Zhenwu Shi, Jie Liu, Jinru Wang   +3 more
doaj   +1 more source

Porous SiC/melamine-derived carbon foam frameworks with excellent electromagnetic wave absorbing capacity

Journal of Advanced Ceramics, 2019
Porous three-dimensional SiC/melamine-derived carbon foam (3D-SiC/MDCF) composite with an original open pore structure was fabricated by the heat treatment of the commercial melamine foam (MF), carbonization of the stable MF, and chemical vapor ...
Xinli Ye, Zhaofeng Chen, Sufen Ai, Bin Hou, Junxiong Zhang, Xiaohui Liang, Qianbo Zhou, Hezhou Liu, Sheng Cui   +8 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Shanghai’s high-rise buildings: exploring space efficiency, structural systems, forms, materials and core designs

Journal of Asian Architecture and Building Engineering
This study examines the architectural and structural design considerations influencing space efficiency in Shanghai’s high-rise buildings. Understanding space efficiency is significant because it directly affects land-use intensity, economic returns, and
Kurt Orkun Aktaş, Özlem Nur Aslantamer, Gözen Güner Aktaş, Hüseyin Emre Ilgın   +3 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Analysis of Space Efficiency in High-Rise Timber Residential Towers

Applied Sciences
High-rise timber residential towers (≥eight-stories) represent a burgeoning and auspicious sector, predominantly due to their capability to provide significant ecological and financial advantages throughout their lifecycle.
Hüseyin Emre Ilgın, Özlem Nur Aslantamer   +1 more
doaj   +1 more source

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

FEBS Letters, EarlyView.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring, Jan de Jonge, Hans‐Peter Braun, Nils Rugen   +3 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source