Results 71 to 80 of about 555,969 (265)

Designing For Vertical Needs: Creating A Ladder Chair For Ergonomic And Space-Saving Solutions

International Journal of Arts Architecture & Design
As creative and academic studio spaces grow increasingly constrained, the demand for multi-functional furniture solutions becomes more critical. This study focused on the design, fabrication, and evaluation of a multifunctional ladder chair that ...
Obed Persie Appiah-Kubi , Evans Kwadwo Donkor   +1 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Correcting a Space-Efficient Simulation Algorithm [PDF]

, 2008
Although there are many efficient algorithms for calculating the simulation preorder on finite Kripke structures, only two have been proposed of which the space complexity is of the same order as the size of the output of the algorithm. Of these, the one with the best time complexity exploits the representation of the simulation problem as a ...
Glabbeek, van, R.J., Ploeger, S.C.W.
openaire   +3 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Space-Efficient Construction of LZ-Index [PDF]

, 2005
A compressed full-text self-index is a data structure that replaces a text and in addition gives indexed access to it, while taking space proportional to the compressed text size. The LZ-index, in particular, requires 4uHk(1+o(1)) bits of space, where u is the text length in characters and Hk is its k-th order empirical entropy.
Arroyuelo Billiardi, Diego, Navarro, Gonzalo   +1 more
openaire   +3 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Efficient Space Exploration through Laziness [PDF]

, 2013
Autonomous behavior and onboard decision making is the backbone of robotic space exploration. The enormous distance and communication latency make such missions hardly controllable from Earth and external decision making may overlap and often contradict with the onboard decision making.
Emil Vassev, Mike Hinchey
openaire   +1 more source

Abnormal ore pressure mechanism of working face under the influence of overlying concentrated coal pillar

Scientific Reports
Shenfu Dongsheng coal field is a cross-century energy base which is developed and constructed in China. In recent years, some mines have successively entered to the coal seam of the second layer.
Cao Zhengzheng, Sun Qiang, Li Zhenhua, Du Feng   +3 more
doaj   +1 more source