Results 91 to 100 of about 1,666,454 (346)

Automated Exploration of Prebiotic Chemical Reaction Space: Progress and Perspectives [PDF]

open access: gold, 2021
Siddhant Sharma   +3 more
openalex   +1 more source

Space exploration and world peace [PDF]

open access: yes
The possibility of using space exploration as an instrument in procuring world peace is studied. Suggestions for obtaining such a peace, utilizing space programs, include removal of worldwide educational and communication barriers, building of an ...
Mercieca, C.
core   +1 more source

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

open access: yesFEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao   +7 more
wiley   +1 more source

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

open access: yesFEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui   +3 more
wiley   +1 more source

The use of acoustics in space exploration

open access: yes, 2007
In recent years increased attention has been paid to the potential uses of acoustics forextraterrestrial exploration. The extent to which acoustics per se is used in these studiesvaries greatly. First, there are the cases in which acoustics is simply the
Leighton, T.G.
core  

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

open access: yesFEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan   +6 more
wiley   +1 more source

Trade studies for nuclear space power systems [PDF]

open access: yes
As human visions of space applications expand and as we probe further out into the universe, our needs for power will also expand, and missions will evolve which are enabled by nuclear power.
Bents, David J.   +2 more
core   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

open access: yesFEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah   +8 more
wiley   +1 more source

Cross-Domain Fault Diagnosis Using Knowledge Transfer Strategy: A Review

open access: yesIEEE Access, 2019
Data-driven fault diagnosis has been a hot topic in recent years with the development of machine learning techniques. However, the prerequisite that the training data and the test data should follow an identical distribution prevents the conventional ...
Huailiang Zheng   +6 more
doaj   +1 more source

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