Results 71 to 80 of about 1,666,454 (346)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Descent trajectory reconstruction and landing site positioning of Chang’E-4 on the lunar farside

Nature Communications, 2019
The Chang’E-4 mission in January 2019 had the major challenge to land on the lunar far side without traditional radiometric techniques due to the missing line-of-sight.
Jianjun Liu, Xin Ren, Wei Yan, Chunlai Li, He Zhang, Yang Jia, Xingguo Zeng, Wangli Chen, Xingye Gao, Dawei Liu, Xu Tan, Xiaoxia Zhang, Tao Ni, Hongbo Zhang, Wei Zuo, Yan Su, Weibin Wen   +16 more
doaj   +1 more source

Improvement of Durability of Hybrid Ceramic Ball Bearings in Liquid Hydrogen at 3 Million DN (120,000 rpm)

Tribology Online, 2010
The durability of a hybrid ceramic 25-mm-bore ball bearing having a single outer land-guided retainer was evaluated and improved in liquid hydrogen at speeds up to 120,000 rpm (120,000 min-1) (3 million DN) by comparing the propagation of superficial ...
Masataka Nosaka, Satoshi Takada, Makoto Yoshida, Masataka Kikuchi, Takayuki Sudo, Shohei Nakamura   +5 more
doaj   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Telescopes and space exploration [PDF]

The necessity for different types of telescopes for astronomical investigations is discussed. Major findings in modern astronomy by ground-based and spaceborne telescopes are presented. Observations of the Crab Nebula, solar flares, interstellar gas, and
Brandt, J. C., Maran, S. P.
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Design and Analysis of a Micro–Electro-Mechanical System Thruster for Small Satellites and Low-Thrust Propulsion

Aerospace
As a cost-effective and versatile solution, small satellites are increasingly being considered for space exploration. However, one of the major challenges in deploying small satellites for high total impulse missions, particularly deep space exploration,
Yubin Zhong, Fabrizio Ponti, Francesco Barato, Guojun Xia, Siyu Li, Xiao Zhang, Tao Wu   +6 more
doaj   +1 more source

Initial performance of the radio occultation experiment in the Venus orbiter mission Akatsuki

Earth, Planets and Space, 2017
After the arrival of Akatsuki spacecraft of Japan Aerospace Exploration Agency at Venus in December 2015, the radio occultation experiment, termed RS (Radio Science), obtained 19 vertical profiles of the Venusian atmosphere by April 2017.
Takeshi Imamura, Hiroki Ando, Silvia Tellmann, Martin Pätzold, Bernd Häusler, Atsushi Yamazaki, Takao M. Sato, Katsuyuki Noguchi, Yoshifumi Futaana, Janusz Oschlisniok, Sanjay Limaye, R. K. Choudhary, Yasuhiro Murata, Hiroshi Takeuchi, Chikako Hirose, Tsutomu Ichikawa, Tomoaki Toda, Atsushi Tomiki, Takumi Abe, Zen-ichi Yamamoto, Hirotomo Noda, Takahiro Iwata, Shin-ya Murakami, Takehiko Satoh, Tetsuya Fukuhara, Kazunori Ogohara, Ko-ichiro Sugiyama, Hiroki Kashimura, Shoko Ohtsuki, Seiko Takagi, Yukio Yamamoto, Naru Hirata, George L. Hashimoto, Manabu Yamada, Makoto Suzuki, Nobuaki Ishii, Tomoko Hayashiyama, Yeon Joo Lee, Masato Nakamura   +38 more
doaj   +1 more source

Feasible-metabolic-pathway-exploration technique using chemical latent space [PDF]

, 2020
Taiki Fuji, Shiori Nakazawa, Kiyoto Ito
openalex   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source