Results 71 to 80 of about 1,638,848 (302)

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Design and Analysis of a Micro–Electro-Mechanical System Thruster for Small Satellites and Low-Thrust Propulsion

Aerospace
As a cost-effective and versatile solution, small satellites are increasingly being considered for space exploration. However, one of the major challenges in deploying small satellites for high total impulse missions, particularly deep space exploration,
Yubin Zhong, Fabrizio Ponti, Francesco Barato, Guojun Xia, Siyu Li, Xiao Zhang, Tao Wu   +6 more
doaj   +1 more source

Initial performance of the radio occultation experiment in the Venus orbiter mission Akatsuki

Earth, Planets and Space, 2017
After the arrival of Akatsuki spacecraft of Japan Aerospace Exploration Agency at Venus in December 2015, the radio occultation experiment, termed RS (Radio Science), obtained 19 vertical profiles of the Venusian atmosphere by April 2017.
Takeshi Imamura, Hiroki Ando, Silvia Tellmann, Martin Pätzold, Bernd Häusler, Atsushi Yamazaki, Takao M. Sato, Katsuyuki Noguchi, Yoshifumi Futaana, Janusz Oschlisniok, Sanjay Limaye, R. K. Choudhary, Yasuhiro Murata, Hiroshi Takeuchi, Chikako Hirose, Tsutomu Ichikawa, Tomoaki Toda, Atsushi Tomiki, Takumi Abe, Zen-ichi Yamamoto, Hirotomo Noda, Takahiro Iwata, Shin-ya Murakami, Takehiko Satoh, Tetsuya Fukuhara, Kazunori Ogohara, Ko-ichiro Sugiyama, Hiroki Kashimura, Shoko Ohtsuki, Seiko Takagi, Yukio Yamamoto, Naru Hirata, George L. Hashimoto, Manabu Yamada, Makoto Suzuki, Nobuaki Ishii, Tomoko Hayashiyama, Yeon Joo Lee, Masato Nakamura   +38 more
doaj   +1 more source

Developing Experimental Models for NASA Missions with ASSL

, 2010
NASA's new age of space exploration augurs great promise for deep space exploration missions whereby spacecraft should be independent, autonomous, and smart.
Hinchey, Mike, Vassev, Emil
core   +2 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Astrotheology: A proactive contextualization of novelty within space exploration

, 2021
A.C. Pieterse
openalex   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

The idea of space exploration [PDF]

Public reactions to the space program, especially to the 1969 Moon landing are discussed. Space exploration is compared to explorations during the Age of Discovery.
Mazlish, B.
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source