Results 81 to 90 of about 1,689,894 (342)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Descent trajectory reconstruction and landing site positioning of Chang’E-4 on the lunar farside
Nature Communications, 2019 The Chang’E-4 mission in January 2019 had the major challenge to land on the lunar far side without traditional radiometric techniques due to the missing line-of-sight.
Jianjun Liu +16 more
doaj +1 more source
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Design-Space Exploration of Application-specific Instruction-set Processor Design
, 2021 Mahdi Sargolzaei
openalex +2 more sources
The idea of space exploration [PDF]
Public reactions to the space program, especially to the 1969 Moon landing are discussed. Space exploration is compared to explorations during the Age of Discovery.
Mazlish, B.
core +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
A Simplified Extension of Physics-Based Single Particle Model for Dynamic Discharge Current
IEEE Access, 2019 The prediction of the battery temperature and terminal voltage under dynamic load condition is crucial for a satellite battery management system. Restricted by parameter measurability and computing resources, equivalent circuit model has been commonly ...
Jinglong Chen +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Space exploration and world peace [PDF]
The possibility of using space exploration as an instrument in procuring world peace is studied. Suggestions for obtaining such a peace, utilizing space programs, include removal of worldwide educational and communication barriers, building of an ...
Mercieca, C.
core +1 more source