Results 51 to 60 of about 143,631 (265)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Environmental and Climate Technologies, 2021 Temperature difference between supply and return distribution medium (water) is a vital factor when assessing the efficiency of a district heating (DH) substation.
Chicherin Stanislav +5 more
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Direct Utilization of Geothermal Energy
Energies, 2010 The worldwide application of geothermal energy for direct utilization is reviewed. This paper is based on the world update for direct-use presented at the World Geothermal Congress 2010 in Bali, Indonesia (WGC2010) [1] which also includes material ...
John W. Lund
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Model Analysis of Solar Thermal System with the Effect of Dust Deposition on the Collectors
Energies, 2018 In this study, a TraNsient SYStems (TRNSYS) simulation model for solar thermal systems is developed to assess the potential of solar energy utilization in cold climate zones, such as Ulaanbaatar (Mongolia), which is one of the five cities with the worst ...
Purevdalai Erdenedavaa +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Applied Sciences, 2018 Air source heat pump (ASHP) is becoming a substitute for small coal boilers in rural residential buildings of North China. However, the application of ASHP faces challenges of heating capacity, energy efficiency, ozone depletion potential (ODP) and ...
Xiangrui Kong, Yufeng Zhang, Jinzhe Nie
doaj +1 more source
Environmental Research: Infrastructure and Sustainability, 2023 Canada has more than 350 remote and northern communities, most of which rely on diesel for their electric and thermal needs. This reliance is deleterious to climate, health, albedo, and energy security—all diesel must be imported.
Ian Maynard, Ahmed Abdulla
doaj +1 more source