Results 51 to 60 of about 30,463 (266)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Future of central heating of university campus – Phasing in clean sustainable alternatives

Energy Reports
University campuses often use central heating systems fueled with fossil fuels for space heating and hot water supplies. In the Northeast United States, it is common to see the use of energy is greater for space heating relative to the total energy ...
Tomas Korinek, Sukesh Aghara, Lohith Annadevula, Radek Skoda   +3 more
doaj   +1 more source

Electron and proton heating by solar wind turbulence

, 2009
Previous formulations of heating and transport associated with strong magnetohydrodynamic (MHD) turbulence are generalized to incorporate separate internal energy equations for electrons and protons. Electron heat conduction is included.
Matthaeus, William H., Cranmer, S.R., Oughton, Sean, S. R. Cranmer, S. Oughton, J. C. Kasper, W. H. Matthaeus, Kasper, J.C., B. Breech, Breech, Ben   +9 more
core   +1 more source

Electron Bulk Heating at Saturn's Magnetopause [PDF]

, 2021
Magnetic reconnection at the magnetopause (MP) energises ambient plasma via the release of magnetic energy and produces an “open” magnetosphere allowing solar wind particles to directly enter the system.
P. Guio, G. Lewis, Achilleos, Nicholas, M. Kane, Achilleos, N, Lewis, Gethyn R, Kane, Mark, I. Cheng, Masters, A, Lewis, G, Cheng, I Kit, Cheng, I, Masters, Adam, N. Achilleos, Guio, P, A. Masters, Kane, M, Guio, Patrick   +17 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Sustainable Heating Analysis and Energy Model Development of a Community Building in Kuujjuaq, Nunavik

Thermo
Energy transition is a challenge for remote northern communities mainly relying on diesel for electricity generation and space heating. Solar-assisted ground-coupled heat pump (SAGCHP) systems represent an alternative that was investigated in this study ...
Alice Cavalerie, Jasmin Raymond, Louis Gosselin, Jean Rouleau, Ali Hakkaki-Fard   +4 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Ionospheric electron heating, optical emissions, and striations induced by powerful HF radio waves at high latitudes: Aspect angle dependence [PDF]

, 2003
In recent years, large electron temperature increases of 300% (3000 K above background) caused by powerful HF-radio wave injection have been observed during nighttime using the EISCAT incoherent scatter radar near Tromsø in northern Norway.
Rietveld, M. T., Kosch, M., Leyser, T., Kosch, Mike J., Rietveld, M., Leyser, T. B., Blagoveshchenskaya, N., Blagoveshchenskaya, N. F., Kornienko, V. A., Yeoman, T. K., Kornienko, V., Yeoman, T.   +11 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source