Results 41 to 50 of about 7,457,271 (296)

Optimization of RNA extraction for bacterial whole transcriptome studies of low-biomass samples

iScience, 2022
Summary: We developed a procedure for extracting maximal amounts of high-quality RNA from low-biomass producing (autotrophic) bacteria for experiments where sample volume is limited.
Tom Verbeelen, Rob Van Houdt, Natalie Leys, Ramon Ganigué, Felice Mastroleo   +4 more
doaj   +1 more source

Muscle atrophy phenotype gene expression during spaceflight is linked to a metabolic crosstalk in both the liver and the muscle in mice

iScience, 2022
Summary: Human expansion in space is hampered by the physiological risks of spaceflight. The muscle and the liver are among the most affected tissues during spaceflight and their relationships in response to space exposure have never been studied.
Geraldine Vitry, Rebecca Finch, Gavin Mcstay, Afshin Behesti, Sébastien Déjean, Tricia Larose, Virginia Wotring, Willian Abraham da Silveira   +7 more
doaj   +1 more source

A PARADIGM SHIFT FROM TELEMEDICINE TO AUTONOMOUS HUMAN HEALTH AND PERFORMANCE FOR LONG-DURATION SPACE MISSIONS

International Journal of Prognostics and Health Management, 2019
This paper discusses a Prognostics and Health Management [PHM]-based approach to implementing Human Health & Performance [HH&P] technologies. Targeted specifically are NASA Autonomous Medical Decision and Integrated Biomedical Informatics of Human Health,
Alexandre Popov, Wolfgang Fink, Andrew Hess   +2 more
doaj   +1 more source

The Future of Personalized Medicine in Space: From Observations to Countermeasures

Frontiers in Bioengineering and Biotechnology, 2021
The aim of personalized medicine is to detach from a “one-size fits all approach” and improve patient health by individualization to achieve the best outcomes in disease prevention, diagnosis and treatment.
E. Pavez Loriè, S. Baatout, A. Choukér, Judith-Irina Buchheim, Bjorn Baselet, C. Dello Russo, V. Wotring, M. Monici, L. Morbidelli, D. Gagliardi, Julia C Stingl, L. Surdo, V. Yip   +12 more
semanticscholar   +1 more source

Enhancing European capabilities for application of multi-omics studies in biology and biomedicine space research

iScience, 2023
Summary: Following on from the NASA twins’ study, there has been a tremendous interest in the use of omics techniques in spaceflight. Individual space agencies, NASA’s GeneLab, JAXA's ibSLS, and the ESA-funded Space Omics Topical Team and the ...
Aránzazu Manzano, Silvio Weging, Daniela Bezdan, Joseph Borg, Thomas Cahill, Eugénie Carnero-Diaz, Henry Cope, Colleen S. Deane, Timothy Etheridge, Stefania Giacomello, Gary Hardiman, Natalie Leys, Pedro Madrigal, Felice Mastroleo, F. Javier Medina, Jakub Mieczkowski, Manuel A. Fernandez-Rojo, Keith Siew, Nathaniel J. Szewczyk, Stephen B. Walsh, Willian A. da Silveira, Raúl Herranz   +21 more
doaj   +1 more source

Ultrasound Biomicroscopy as a Novel, Potential Modality to Evaluate Anterior Segment Ophthalmic Structures during Spaceflight: An Analysis of Current Technology

Diagnostics
Ocular health is currently a major concern for astronauts on current and future long-duration spaceflight missions. Spaceflight-associated neuro-ocular syndrome (SANS) is a collection of ophthalmic and neurologic findings that is one potential ...
Benjamin Soares, Joshua Ong, Daniela Osteicoechea, Cihan Mehmet Kadipasaoglu, Ethan Waisberg, Prithul Sarker, Nasif Zaman, Alireza Tavakkoli, Gianmarco Vizzeri, Andrew G. Lee   +9 more
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Space omics research in Europe: Contributions, geographical distribution and ESA member state funding schemes

iScience, 2022
Summary: The European research community, via European Space Agency (ESA) spaceflight opportunities, has significantly contributed toward our current understanding of spaceflight biology.
Colleen S. Deane, Willian A. da Silveira, Raúl Herranz, Colleen S. Deane, Joseph Borg, Thomas Cahill, Eugénie Carnero-Diaz, Timothy Etheridge, Gary Hardiman, Natalie Leys, Pedro Madrigal, Aránzazu Manzano, Felice Mastroleo, F. Javier Medina, Manuel A. Fernandez-Rojo, Keith Siew, Nathaniel J. Szewczyk, Alicia Villacampa, Stephen B. Walsh, Silvio Weging, Daniela Bezdan, Stefania Giacomello, Willian A. da Silveira, Raúl Herranz   +23 more
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Cell-free DNA (cfDNA) and Exosome Profiling from a Year-Long Human Spaceflight Reveals Circulating Biomarkers

iScience, 2020
Summary: Liquid biopsies based on cell-free DNA (cfDNA) or exosomes provide a noninvasive approach to monitor human health and disease but have not been utilized for astronauts.
Daniela Bezdan, Kirill Grigorev, Cem Meydan, Fanny A. Pelissier Vatter, Michele Cioffi, Varsha Rao, Matthew MacKay, Kiichi Nakahira, Philip Burnham, Ebrahim Afshinnekoo, Craig Westover, Daniel Butler, Chris Mozsary, Timothy Donahoe, Jonathan Foox, Tejaswini Mishra, Serena Lucotti, Brinda K. Rana, Ari M. Melnick, Haiying Zhang, Irina Matei, David Kelsen, Kenneth Yu, David C. Lyden, Lynn Taylor, Susan M. Bailey, Michael P. Snyder, Francine E. Garrett-Bakelman, Stephan Ossowski, Iwijn De Vlaminck, Christopher E. Mason   +30 more
doaj   +1 more source