Results 41 to 50 of about 5,022 (266)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Theoretical Perspective on the Occurrence of Electrostatic Solitary Waves and Double Layers in Ganymede’s Wake Region

The Astrophysical Journal
The first close flyby of Ganymede by Juno on 2021 June 7 provided a unique opportunity to visit the previously unexplored wake and magnetopause regions.
R. Rubia, M. B. Dhanya, Kuldeep Singh, Ioannis Kourakis   +3 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Whistler mode waves and Hall fields detected by MMS during a dayside magnetopause crossing

Geophysical Research Letters, 2016
We present Magnetospheric Multiscale (MMS) mission measurements during a full magnetopause crossing associated with an enhanced southward ion flow. A quasi‐steady magnetospheric whistler mode wave emission propagating toward the reconnection region with ...
O. Le Contel, A. Retinò, H. Breuillard, L. Mirioni, P. Robert, A. Chasapis, B. Lavraud, T. Chust, L. Rezeau, F. D. Wilder, D. B. Graham, M. R. Argall, D. J. Gershman, P.‐A. Lindqvist, Y. V. Khotyaintsev, G. Marklund, R. E. Ergun, K. A. Goodrich, J. L. Burch, R. B. Torbert, J. Needell, M. Chutter, D. Rau, I. Dors, C. T. Russell, W. Magnes, R. J. Strangeway, K. R. Bromund, H. K. Leinweber, F. Plaschke, D. Fischer, B. J. Anderson, G. Le, T. E. Moore, C. J. Pollock, B. L. Giles, J. C. Dorelli, L. Avanov, Y. Saito   +38 more
doaj   +1 more source

The proton pressure tensor as a new proxy of the proton decoupling region in collisionless magnetic reconnection [PDF]

Annales Geophysicae, 2011
Cluster data is analyzed to test the proton pressure tensor variations as a proxy of the proton decoupling region in collisionless magnetic reconnection.
N. Aunai, A. Retinò, G. Belmont, R. Smets, B. Lavraud, B. Lavraud, A. Vaivads   +6 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Energy Flux Densities in Electron-only Magnetic Reconnection in Space Plasma

The Astrophysical Journal Supplement Series
Electron-only magnetic reconnection, a novel form of magnetic reconnection recently discovered in plasma turbulence, exhibits distinct features from the well-studied standard magnetic reconnection with ion coupling.
Z. Z. Chen, T. Y. Wang, J. Yu, J. Wang, Y. D. Ye, H. S. Fu, J. B. Cao, J. Cui, H. Y. Man, Y. C. Jiang   +9 more
doaj   +1 more source

Collisionless Magnetic Reconnection in Space Plasmas

Frontiers in Physics, 2013
Magnetic reconnection, the merging of oppositely directed magnetic fields that leads to field reconfiguration, plasma heating, jetting and acceleration, is one of the most celebrated processes in collisionless plasmas.
Rudolf A. Treumann, Wolfgang eBaumjohann
doaj   +1 more source

Space-Time Structured Plasma Waves

Physical Review Letters
Electrostatic waves play a critical role in nearly every branch of plasma physics from fusion to advanced accelerators, to astro, solar, and ionospheric physics. The properties of planar electrostatic waves are fully determined by the plasma conditions, such as density, temperature, ionization state, or details of the distribution functions.
J. P. Palastro, K. G. Miller, R. K. Follett, D. Ramsey, K. Weichman, A. V. Arefiev, D. H. Froula   +6 more
openaire   +3 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source