Results 81 to 90 of about 6,903,043 (357)

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Simulation of grid morphology’s effect on ion optics and the local electric field

AIP Advances, 2022
Electric field ion optics are employed by many scientific instruments for investigating ions, e.g., using time-of-flight mass spectrometers. A common design feature of such instruments is the grounded grid that provides boundaries between regions that ...
Z. Levin, S. Kempf
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Energy Flux Densities in Electron-only Magnetic Reconnection in Space Plasma

The Astrophysical Journal Supplement Series
Electron-only magnetic reconnection, a novel form of magnetic reconnection recently discovered in plasma turbulence, exhibits distinct features from the well-studied standard magnetic reconnection with ion coupling.
Z. Z. Chen, T. Y. Wang, J. Yu, J. Wang, Y. D. Ye, H. S. Fu, J. B. Cao, J. Cui, H. Y. Man, Y. C. Jiang   +9 more
doaj   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Periodically Modulated Magnetic Reconnection

The Astrophysical Journal
We present the first evidence for periodically modulated reconnection at the electron scale in space, using unparalleled, high-cadence data from Magnetospheric Multiscale spacecraft.
Chengming Liu, Jinbin Cao, Xining Xing, Yangyang Liu, Boning Zhao   +4 more
doaj   +1 more source

Rogue waves in space dusty plasmas [PDF]

, 2017
The modulational instability of dust-acoustic (DA) waves (DAWs) and corresponding DA rogue waves (DARWs) in a realistic space dusty plasma system (containing inertial warm positively and negatively charged dust, isothermal ions, and super-thermal kappa ...
N. A. Chowdhury, Abdullah Al Mamun
semanticscholar   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

On the Origin of Polytropic Behavior in Space and Astrophysical Plasmas

Astrophysical Journal, 2019
It is shown that the polytropic behavior—a specific power-law relationship among the thermal plasma moments—restricts the functional form of the distribution of particle velocities and energies.
G. Livadiotis
semanticscholar   +1 more source

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin, Haocheng Yang, Feng Liu, Sihao Lin, Junru Hu, Jian Wang, Yulan Gou   +6 more
wiley   +1 more source