Results 91 to 100 of about 7,665,377 (334)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Whistler mode waves and Hall fields detected by MMS during a dayside magnetopause crossing

Geophysical Research Letters, 2016
We present Magnetospheric Multiscale (MMS) mission measurements during a full magnetopause crossing associated with an enhanced southward ion flow. A quasi‐steady magnetospheric whistler mode wave emission propagating toward the reconnection region with ...
O. Le Contel, A. Retinò, H. Breuillard, L. Mirioni, P. Robert, A. Chasapis, B. Lavraud, T. Chust, L. Rezeau, F. D. Wilder, D. B. Graham, M. R. Argall, D. J. Gershman, P.‐A. Lindqvist, Y. V. Khotyaintsev, G. Marklund, R. E. Ergun, K. A. Goodrich, J. L. Burch, R. B. Torbert, J. Needell, M. Chutter, D. Rau, I. Dors, C. T. Russell, W. Magnes, R. J. Strangeway, K. R. Bromund, H. K. Leinweber, F. Plaschke, D. Fischer, B. J. Anderson, G. Le, T. E. Moore, C. J. Pollock, B. L. Giles, J. C. Dorelli, L. Avanov, Y. Saito   +38 more
doaj   +1 more source

Inertial range turbulence in kinetic plasmas

, 2007
The transfer of turbulent energy through an inertial range from the driving scale to dissipative scales in a kinetic plasma followed by the conversion of this energy into heat is a fundamental plasma physics process.
Braginskii S. I., Gregory G. Howes, Iroshnikov R. S., Iroshnikov R. S.   +3 more
core   +1 more source

Derivation of the entropic formula for the statistical mechanics of space plasmas

, 2017
. Kappa distributions describe velocities and energies of plasma populations in space plasmas. The statistical origin of these distributions is associated with the framework of nonextensive statistical mechanics. Indeed, the kappa distribution is derived
G. Livadiotis
semanticscholar   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Energy Flux Densities in Electron-only Magnetic Reconnection in Space Plasma

The Astrophysical Journal Supplement Series
Electron-only magnetic reconnection, a novel form of magnetic reconnection recently discovered in plasma turbulence, exhibits distinct features from the well-studied standard magnetic reconnection with ion coupling.
Z. Z. Chen, T. Y. Wang, J. Yu, J. Wang, Y. D. Ye, H. S. Fu, J. B. Cao, J. Cui, H. Y. Man, Y. C. Jiang   +9 more
doaj   +1 more source

Direct evidence of substorm-related impulsive injections of electrons at Mercury

Nature Communications, 2023
Mercury’s magnetosphere is known to involve fundamental processes releasing particles and energy like at Earth due to the solar wind interaction. The resulting cycle is however much faster and involves acceleration, transport, loss, and recycling of ...
Sae Aizawa, Yuki Harada, Nicolas André, Yoshifumi Saito, Stas Barabash, Dominique Delcourt, Jean-André Sauvaud, Alain Barthe, Andréi Fedorov, Emmanuel Penou, Shoichiro Yokota, Wataru Miyake, Moa Persson, Quentin Nénon, Mathias Rojo, Yoshifumi Futaana, Kazushi Asamura, Manabu Shimoyama, Lina Z. Hadid, Dominique Fontaine, Bruno Katra, Markus Fraenz, Norbert Krupp, Shoya Matsuda, Go Murakami   +24 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Quasithermal Noise in Magnetized Plasma: Theory and Simulations

The Astrophysical Journal
Quasithermal noise (QTN) spectroscopy has been extensively used as an accurate tool to measure electron density and temperature in unmagnetized space plasmas. The observed spectrum depends on both antenna geometry and plasma kinetic properties.
Xianming Zheng, Mihailo M. Martinović, Kristopher G. Klein, Viviane Pierrard, Mingzhe Liu, Xianghui Xue, Shi Tao, Kun Cheng, Han Wu, Bingkun Yu   +9 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source