Results 51 to 60 of about 66,871 (310)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Space Detumbling Robot Arm Deployment Path Planning Based on Bi-FMT* Algorithm

Micromachines, 2021
In order to avoid damage to service satellites and targets during space missions and improve safety and reliability, it is necessary to study how to eliminate or reduce the rotation of targets.
Ning Chen, Yasheng Zhang, Wenhua Cheng
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

A review on planning and control of space robots for on-orbit capture

工程科学学报
With the rapid development of space technology, space robots are playing an important role in on-orbit services, such as refueling, debris removal, and malfunctioning satellite repair.
Qian SUN, Linshuo ZHENG, Yingmin JIA
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Towards an Architecture for Semiautonomous Robot Telecontrol Systems.

, 2009
The design and development of a computational system to support robot–operator collaboration is a challenging task, not only because of the overall system complexity, but furthermore because of the involvement of different technical and scientific ...
Triviño Barros, Gracián, Van der Heide, Albert, Mengual Galan, Luis   +2 more
core   +2 more sources

Adaptive Neural Network-Based Fixed-Time Trajectory Tracking Control of Space Robot with Uncertainties and Input Nonlinearities

Aerospace
In this paper, a fixed-time control strategy based on neural networks is proposed for a space robot with an input dead zone. First, a model-based control method is proposed based on the fixed-time convergence framework.
Haiping Ai, Lei Jiang, An Zhu, Xiaodong Fu   +3 more
doaj   +1 more source

Method of preliminary solution of the problem of space robot navigation by onboard astronomical measurements using the butterworth filter

Вестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение, 2020
A method of preliminary solution of the problem of space robot navigation based on the results of measurements carried out using its onboard optronic equipment is presented.
V. M. Ananenko, A. D. Golyakov, P. V. Kalabin   +2 more
doaj   +1 more source