Results 211 to 220 of about 20,474,455 (275)

Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids

Angewandte Chemie, EarlyView.
Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar, Manas Joshi, Abhishek Chatterjee   +2 more
wiley   +1 more source

Piezo channels in physical field therapy: From mechanotransduction mechanisms to bioelectromagnetic modulation and biomedical applications. [PDF]

Mechanobiol Med
Li B, Kang HM, Pan WD, Li Y.
europepmc   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +1 more source

Acyclic Glutarimide PROTAC Precursors Enable Controlled Protein Degradation and Expand Cereblon Ligand Space. [PDF]

ACS Med Chem Lett
Renner AC, Kargbo RB.
europepmc   +1 more source

A de‐novo Approach Towards Divergent [3+2π/σ] Photocycloadditions of Nitrones via Assembly‐Controlled Kinetic Electron Transfer Gating

Angewandte Chemie, EarlyView.
A metal‐free photocatalytic platform converts nitrones into 4‐isoxazolines and oxa–aza–bicycloheptanes through divergent [3+2π/σ] cycloadditions. Assembly‐controlled kinetic electron transfer gating dictates substrate activation, enabling selective reactivity beyond thermodynamic expectations.
Nayan Saha, Rajesh Kancherla, Jorge Escorihuela, Shana Chandran, Mrinal K. Bera, Magnus Rueping, Burkhard König   +6 more
wiley   +1 more source

Ligand‐Directed Molecular Beacons as Turn‐On Fluorescent Probes for Sensing Cell‐Surface Receptor‐Ligand Interactions

Angewandte Chemie, EarlyView.
Multivalent, ligand‐directed molecular beacons enable fluorescence turn‐on detection of cell‐surface receptors in living cells. The probes strongly engage closely spaced membrane receptors and exhibit conformation‐dependent fluorescence enhancement at the cell surface, enabling wash‐free receptor imaging, inhibitor screening, and functional evaluation ...
Noa Oppenheimer‐Low, Denis Shpalter, Suraj Toraskar, Martín López‐Vidal, Ziv Porat, Inna Goliand, Ekaterina Petrovich‐Kopitman, Noga Kozer, Haim Michael Barr, Alla H. Falkovich, Leila Motiei, David Margulies   +11 more
wiley   +1 more source

A tutorial for mesoscale computer simulations of lipid membranes: tether pulling, tubulation and fluctuations.

Soft Matter
Muñoz-Basagoiti M, Frey F, Meadowcroft B, Amaral M, Prada A, Šarić A.   +5 more
europepmc   +1 more source

Cellular replisomes are powered by flex-fuel motors for unwinding DNA. [PDF]

Nat Commun
Rashid F, Pangeni S, Liu C, Kumar H, Moon GS, Yan Q, Ha T, Berger JM.   +7 more
europepmc   +1 more source

Gold Clusters With Open‐Shell Ligands: Superatom Mediated Magnetic Interaction

Angewandte Chemie, EarlyView.
Open‐shell verdazyl radicals were covalently integrated with atomically precise Ir‐doped Au12 (Ir@Au12) superatoms. The resulting radical–superatom hybrids exhibit photoinduced electron transfer, spin delocalization onto the metal‐cluster core, and weak ferromagnetic communication between radicals mediated by the superatomic electronic structure ...
Katsuya Mutoh, Kosei Hayashi, Yoichi Kobayashi, Kazunobu Sato, Rika Tanaka, Daichi Kitagawa, Tatsuya Tsukuda, Takuya Nakashima   +7 more
wiley   +1 more source

The Right Strap: The Role of Tether Position and Length in Acene Distortion. [PDF]

Org Lett
Shioukhi I, Agrawal A, Deree Y, Bogoslavsky B, Gidron O.   +4 more
europepmc   +1 more source