Results 221 to 230 of about 20,474,455 (275)

Should I Stay or Should I Go—Leveraging an Overlooked Feature of Click‐to‐Release Chemistry for Affinity Labeling

Angewandte Chemie, EarlyView.
Click‐to‐release (C2R) chemistry is redirected from payload liberation toward ligand‐directed covalent protein labeling through a transient dihydropyridazine methide (DHP‐methide). This concept opens the way to dual‐functional systems combining covalent target engagement with controlled effector release.
Dóra Kern, Krisztina Németh, Tímea Imre, József Simon, Kitti Meggyes, Gergő Bárdos, László Petri, Márton Bojtár, Attila Kormos, Péter Kele   +9 more
wiley   +1 more source

Network mechanisms of glymphatic system dysfunction in the disruption of the "brain-lung axis". [PDF]

Front Neurol
Mao L, Yang Z, Jiang F.
europepmc   +1 more source

Intramolecular Nickel‐Catalyzed Reductive Coupling: Enantioselective Synthesis of Tetrahydroisoquinolines and Related Heterocycles

Angewandte Chemie, EarlyView.
The successful extension of the nickel‐catalyzed asymmetric coupling of polarized 1,3‐dienes with aldehydes to an intramolecular setting opens an efficient new entry into hydroxylated N‐heterocyclic compounds, most notably valuable tetrahydroisoquinolines.
Thilo Bender, Markus Leutzsch, Yannik Sell, Alois Fürstner   +3 more
wiley   +1 more source

Something old, something new? Herpesvirus genome packaging examined in light of lessons from the tailed bacteriophages. [PDF]

J Virol
Meißner LM, Shiah JV, Adeyemi OA, Bailey EJ, Gelles-Watnick S, Didychuk AL.   +5 more
europepmc   +1 more source

Mechanical Signatures of Nucleic Acid Trefoil Knot Topology

Angewandte Chemie, EarlyView.
Single‐stranded DNA can be designed with sequences that self‐thread into topological knots. The exact same sequence can alternatively be turned into an unknotted pseudoknot. The topology of the resulting polymer is determined by applying force with optical tweezers, causing the pseudoknot to resolve but the knot to tighten.
David t.R. Bakker, Micah Yang, Isaac T. S. Li   +2 more
wiley   +1 more source

Soft tissue mechanosensing and remodeling: the core regulatory role of Piezo/TRPV4 ion channels. [PDF]

Front Cell Dev Biol
Fan X, Shi M, Wang Z, Zhao C, Zhao Y, Zhou Y, Xu H.   +6 more
europepmc   +1 more source

Broad‐Spectrum, Cell Envelope‐Active Marinocyclin Antibiotics From a Coral‐Derived Bacterium Are Effective Against Colistin‐Resistant Bacteria

Angewandte Chemie, EarlyView.
Marinocyclins, polycationic macrocyclic depsipeptides, were discovered by genome mining from the marine coral‐derived bacterium Aquimarina megaterium. The compounds have broad‐spectrum activity against gram‐positive and gram‐negative ESKAPE bacteria.
Clara Chepkirui, Sandra Silva, Jan Straetener, Chandrashekhar Padhi, Tina Keller‐Costa, Tess Lamer, Laura Reinke, Heike Brötz‐Oesterhelt, Rodrigo Costa, Jörn Piel   +9 more
wiley   +1 more source

Inter-Organelle Membrane Contact Sites as Physiological Regulatory Hubs in the Brain: From Neurons to Glial Cells. [PDF]

Biomolecules
Wu Y, Cho G, Lim Y.
europepmc   +1 more source

Aryne-mediated direct assembly of <i>O</i>-bridged seven-membered cyclic diaryliodoniums: access to oxaheteropines and cannabinols <i>via</i> skeletal modification. [PDF]

Chem Sci
Kamioka S, Morohashi S, Kikuchi J, Kwon E, Yoshikai N.   +4 more
europepmc   +1 more source

Seasonal differences in predation risk among seagrass epifauna species stabilize community-level predation over time. [PDF]

Ecology
Murphy CE, Stachowicz JJ.
europepmc   +1 more source