Results 81 to 90 of about 962,783 (305)
Accessibilità al patrimonio culturale: un progetto di Inclusive Research nelle Disabilità Intellettive [PDF]
, 2020 The aim of this work is to investigate accessibility in cultural spaces for people with intellectual disabilities (ID). Inclusive Research, which promotes a type of research with people with disabilities rather than on them, has been chosen as a paradigm
Span, Stefania +3 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Span of Control and Span of Attention
SSRN Electronic Journal, 2014 Using novel data on CEO time use, we document the relationship between the size and composition of the executive team and the attention of the CEO. We combine information about CEO span of control for a sample of 65 companies with detailed data on how CEOs allocate their time, which we define as their span of attention. CEOs with larger executive teams
Oriana Bandiera +3 more
openaire +1 more source
Yeonjoo Park : [moments of silence]
, 2005 Catalogue of an exhibition held at Span Galleries, Melbourne, Victoria, 20 Sep - 1 Oct ...
Span Galleries
core
Multi-Span Extractive Question Answering for Named Entity Recognition [PDF]
, 2023 openNamed Entity Recognition (NER) is a Natural Language Processing (NLP) task that involves detecting and categorizing named entities in a text. Named entities can be names of people, organizations, locations and dates or can be specifically defined for
ZAMAI, ANDREW
core
Cloud-SPAN/01genomics: Cloud-SPAN Genomics Session 1: Project Management for Cloud Genomics
, 2022 <p><a href="https://cloud-span.york.ac.uk/">Cloud-SPAN</a> is a collaboration between the <a href="https://www.york.ac.uk/biology/">Department of Biology</a> at the University of York and <a href ...
Chong, James +5 more
core +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source