Results 121 to 130 of about 213,065 (277)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal +8 morewiley +1 more sourceSPARK: A US Cohort of 50,000 Families to Accelerate Autism Research.
Neuron, 2018 P. Feliciano, A. Daniels, Leeanne Green Snyder, Amy L Beaumont, Alexies Camba, A. Esler, Amanda G. Gulsrud, Andrew Mason, Anibal Gutierrez, Amy G. Nicholson, Anna Marie Paolicelli, Alexander P. McKenzie, A. Rachubinski, Alexandra N. Stephens, Andrea R Simon, Amy Stedman, Amanda D. Shocklee, A. Swanson, B. Finucane, Brittani A. Hilscher, Brenda Hauf, B. O’Roak, Brooke G. McKenna, B. E. Robertson, Barbara Rodriguez, Brianna M. Vernoia, Bonnie Van Metre, Catherine C. Bradley, Cheryl Cohen, C. Erickson, Christina M. Harkins, Caitlin Hayes, C. Lord, C. Martin, Crissy Ortiz, Cesar Ochoa-Lubinoff, C. Peura, C. Rice, C. Rosenberg, Christopher J. Smith, C. Thomas, Cora M. Taylor, L. C. White, Corrie H. Walston, David G. Amaral, D. Coury, Dustin E. Sarver, Dalia Istephanous, Deana D. Li, Dzung Cong Nugyen, Emily A. Fox, E. Butter, E. Berry-Kravis, E. Courchesne, E. Fombonne, Eugenia Hofammann, Elena Lamarche, Ericka L. Wodka, Emily T. Matthews, Eirene O’Connor, Emily Palen, Fiona Miller, G. Dichter, Gabriela Marzano, Gail Stein, H. Hutter, Hannah E. Kaplan, Hai Li, Holly Lechniak, H. Schneider, Hana Zaydens, Ivette Arriaga, J. Gerdts, J. Cubells, Jeanette M Cordova, Jaclyn A. Gunderson, J. Lillard, Julie Manoharan, J. McCracken, J. Michaelson, J. Neely, Jessica Orobio, J. Pandey, J. Piven, Jessica F. Scherr, J. Sutcliffe, Jennifer Tjernagel, Jermel Wallace, Kristen Callahan, Kate Dent, K. Schweers, Kira E. Hamer, J. K. Law, Kathryn R. Lowe, Kaela O’Brien, Kaitlin Smith, Katherine Pawlowski, K. Pierce, K. Roeder, L. Abbeduto, L. Berry, Lindsey A. Cartner, L. Coppola, L. Carpenter, Lisa Cordeiro, L. DeMarco, Luke P Grosvenor, L. Higgins, L. Huang-Storms, Landon Hosmer-Quint, Lynn M. Herbert, Lauren Kasparson, Lisa M. Prock, Lillian D. Pacheco, L. Raymond, Laura Simon, L. Soorya, Lucy Wasserburg, Maya Lazar, M. Alessandri, Melissa Brown, M. Currin, M. Gwynette, Michelle Heyman, Melissa N. Hale, Mark Jones, Michelle Jordy, M. Morrier, M. Sahin, M. Siegel, M. Verdi, Meaghan V Parladé, Meredith Yinger, Nicole Bardett, Nathan Hanna, Nina Harris, Natalie R. Pottschmidt, Nicole M. Russo‐Ponsaran, N. Takahashi, O. Ousley, A. Juárez, Patricia Manning, R. Annett, R. Bernier, R. Clark, R. Landa, R. Goin-Kochel, R. Remington, R. Schultz, S. Brewster, Stephanie Booker, S. Carpenter, S. Eldred, Sunday M. Francis, S. Friedman, S. Horner, S. Hepburn, Suma Jacob, S. Kanne, S. Lee, Sarah A. Mastel, S. Plate, Shanping Qiu, Sophia Sandhu, Samantha Thompson, Sabrina White, V. J. Myers, Vini Singh, Wha S. Yang, Z. Warren, Alpha Amatya, Andrea J. Ace, A. S. Chatha, A. Lash, Ben Negron, Chris Rigby, Curtis Ridenour, Colleen M. Stock, Danielle Schmidt, Ian Fisk, John Acampado, J. Nestle, J. Nestle, Kevin Layman, Martin E. Butler, M. Kent, Malcolm D. Mallardi, N. Carriero, Noah Lawson, N. Volfovsky, Ron Edgar, Richard A Marini, Rishiraj Rana, Swami Ganesan, Swapnil Shah, T. Ramsey, Wubin Chin, William Jensen, Anthony D. Krentz, Angela J. Gruber, A. Sabo, A. Salomatov, C. Eng, D. Muzny, Irina Astrovskaya, R. Gibbs, Xinwei Han, Yufeng Shen, L. Reichardt, Wendy K. Chung +209 moresemanticscholar +1 more sourceA synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote +8 morewiley +1 more sourceMass Erosion and Material Transfer at the Deposition of Layers by Inverse Electroerosion
The Annals of “Dunarea de Jos” University of Galati. Fascicle IX, Metallurgy and Materials Science, 2008 The deposition and alloying of the superficial layers by inverse electroerosion or by electric spark given by a vibrating electrode permits to obtain a large scale of properties at the surface of metallic materials from tools, machines organs, electric ...Adrian ALEXANDRU, Marius HUŢANU, Sorin IACOB STRUGARU +2 moredoaj Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance
Molecular Oncology, EarlyView.Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis +11 morewiley +1 more sourceAggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera +11 morewiley +1 more sourceThe neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal +8 morewiley +1 more source
