Results 131 to 140 of about 55,467 (261)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

The Silent Pandemic: Preventing Non-communicable Diseases from Taking Over the Arabian Gulf

Oman Medical Journal
Wesley Kuijpers
doaj   +1 more source

Up to 30 years of clinical performance of double-crown-retained removable dental prostheses with spark-eroded friction pins placed in a general dental practice. [PDF]

Clin Oral Investig
Zierden K, Werdecker S, Wöstmann B, Rehmann P.   +3 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Data Sharing and Global Public Health: Defining What We Mean by Data

Frontiers in Digital Health, 2020
Nina Schwalbe, Nina Schwalbe, Nina Schwalbe, Brian Wahl, Brian Wahl, Jingyi Song, Susanna Lehtimaki   +6 more
doaj   +1 more source

Scalable fabrication of gas sensors via spark-ablation printing of semiconductive metal oxide nanoparticles and heterostructures. [PDF]

Microsyst Nanoeng
Fu W, Tang Z, Gu Y, Shao X, Zhang J, Hu Z, Zhang M, Li J, Jin Z, Liu X, Tu M.   +10 more
europepmc   +1 more source

Spark life: the biographies of Muriel Spark [PDF]

, 2018
In the last of his blogs on Muriel Spark in her centenary year Professor Willy Maley looks at the ways in which her biographies of other writers shaped her own writing and affected how she responded to life-writing as memoirist and as biographical subject.
openaire  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Remote personalised exercise in axial spondyloarthritis: the SPARK trial - protocol for a 6-month randomised controlled trial. [PDF]

BMJ Open
Nellemann B, Fongen C, Dagfinrud H, Berg IJ, Kristianslund EK, Sexton J, Nordén KR, Lillegraven S, Østerås N, Jørgensen TS, Carmona L, Sveaas SH, Provan SA.   +12 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source