Results 51 to 60 of about 9,389 (307)

Simulations of Compressible, Diffusive, Reactive Flows with Detailed Chemistry Using a High-Order Hybrid WENO-CD Scheme [PDF]

, 2012
A hybrid weighted essentially non-oscillatory (WENO)/centered-difference (CD) numerical method, with low numerical dissipation, high-order shock-capturing, and structured adaptive mesh refinement (SAMR), has been developed for the direct numerical ...
Ziegler, John Lewis (Jack)
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Simulation and Analytical Analysis of the Blumlein Discharge Circuit for the Generation of Coherent UV Pulses in Air

Majlesi Journal of Electrical Engineering
Blumlein discharge circuit stores electrical energy in its transmission line and can release this energy within a few nanoseconds. This leads the Blumlein to discharge circuit for many applications ranging from electrical discharge in the air to generate
Muddasir Naeem, Rabiya Munawar, Mukhtar Hussain, Tayyab Imran, Arshad Bhatti   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The development of the spark discharge. II [PDF]

Proceedings of the Royal Society of London. Series A. Mathematical and Physical Sciences, 1938
Abstract An account has already been given of observations made with a rotating-film camera in the study of the electric spark in air at atmospheric pressure (Aliibone and Meek 1938; Allibone 1938). The object of the present paper is to extend the previous results, and in particular to describe the development of the spark in air at ...
Thomas Edward Allibone, J. M. Meek
openaire   +1 more source

Discharge Characteristics of Current Boosted Spark Events Under Flow Conditions

, 2017
With the advancement of spark ignition engines, lean or diluted in-cylinder charge is often used to improve the engine performance. Enhanced in-cylinder charge motion is widely applied under such conditions to promote the flame propagation, which raise ...
Zhenyi Yang, Mark Ives, Xiao Yu, Shui Yu, Ming Zheng   +4 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Spark discharge-initiated radical polymerization

Next Materials
A new spark discharge initiated radical polymerization (SDRP) was developed. Monomer radicals were generated by spark discharge emitted from a Tesla coil as a resonant transformer generating high frequency and high voltage, and the monomer itself acted ...
Hiromasa Goto, Kyoka Komaba, Kazuki Yanagida, Aoi Tokutake   +3 more
doaj   +1 more source