Results 231 to 240 of about 142,677 (240)

Evolution of Infantile Spasms to Lennox-Gastaut Syndrome: What Is There to Know?

Journal of Child Neurology, 2021
Objective: Children with infantile spasms may develop Lennox-Gastaut syndrome. The diagnostic criteria for Lennox-Gastaut syndrome are vague, and many experts use varying combinations of the following criteria for diagnosis: paroxysmal fast activity on ...
J. Nelson, S. Demarest, Jake Thomas, E. Juarez-colunga, K. Knupp   +4 more
semanticscholar   +1 more source

Cost‐effectiveness of adrenocorticotropic hormone versus oral steroids for infantile spasms

Epilepsia, 2021
To compare the effectiveness and cost‐effectiveness of adrenocorticotropic hormone (ACTH) and oral steroids as first‐line treatment for infantile spasm resolution, we performed a systematic review, meta‐analysis, and cost‐effectiveness study.
Iván Sánchez Fernández, Marta Amengual-Gual, Marina Gaínza-Lein, Cristina Barcia Aguilar, A. Bergin, Christopher J. Yuskaitis, C. Harini   +6 more
semanticscholar   +1 more source

Patterns of Brain Injury in Perinatal Arterial Ischemic Stroke and the Development of Infantile Spasms

Journal of Child Neurology, 2021
Introduction: Perinatal arterial ischemic stroke (PAIS) underlies approximately 10% of infantile spasms (IS). We aim to identify patterns of brain injury in ischemic stroke that may predispose infants to infantile spasms.
R. Srivastava, Oriana Shaw, Edward A. Armstrong, Francois-Dominique Morneau-Jacob, J. Yager   +4 more
semanticscholar   +1 more source

Whole‐exome sequencing and adrenocorticotropic hormone therapy in individuals with infantile spasms

Developmental Medicine & Child Neurology, 2021
To identify additional genes associated with infantile spasms using a cohort with defined infantile spasms.
S. Demarest, Jeff Calhoun, K. Eschbach, Hung-Chun Yu, D. Mirsky, Katie Angione, T. Shaikh, G. Carvill, T. Benke   +8 more
semanticscholar   +1 more source

Predictors of outcome among 31 children with infantile spasms syndrome.

Epileptic disorders, 2021
OBJECTIVE Infantile spasms syndrome is a severe epileptic encephalopathy. Management of infantile spasms remains challenging because of pharmacoresistant forms and relapsing seizures.
A. Kvernadze, N. Tatishvili, G. Lomidze, N. Tarkhnishvili, T. Kipiani, S. Tatishvili   +5 more
semanticscholar   +1 more source

Fulminant vigabatrin toxicity during combination therapy with adrenocorticotropic hormone for infantile spasms: Three cases and review of the literature

Epilepsia, 2020
Vigabatrin (VGB), adrenocorticotropic hormone (ACTH), and prednisone are first‐line treatments for infantile spasms (IS). A recent study reported benefits from the use of combination VGB and hormonal therapy over hormonal treatment alone in IS.
S. Bhalla, K. Skjei
semanticscholar   +1 more source

Treatment of infantile spasms: why do we know so little?

Expert Review of Neurotherapeutics, 2020
Introduction Infantile spasm (IS) is an epileptic syndrome with typical onset within the first 2 years of life. This condition might be caused by several etiologies.
N. Specchio, N. Pietrafusa, A. Ferretti, L. de Palma, M. Santarone, C. Pepi, M. Trivisano, F. Vigevano, P. Curatolo   +8 more
semanticscholar   +1 more source

Neuroinflammation in Children With Infantile Spasms: A Prospective Study Before and After Treatment With Acthar Gel (Repository Corticotropin Injection)

Journal of Child Neurology, 2020
The selective effectiveness of adrenocorticotropic hormone (ACTH) in treating infantile spasms suggests an underlying neuroinflammation. Because neuroinflammation is mediated by activated microglia, which express translocator protein (TSPO), we imaged ...
H. Chugani, Ajay Kumar
semanticscholar   +1 more source

Treatment modalities for infantile spasms: current considerations and evolving strategies in clinical practice

Neurological Sciences, 2023
Payton P Hollenshead, Corrie N Jackson, Jordan V Cross, Taylor E Witten, Ahmed I Anwar, Shahab Ahmadzadeh, Sahar Shekoohi, A. Kaye   +7 more
semanticscholar   +1 more source

Infantile Spasms: Outcome in Clinical Studies.

Pediatric Neurology, 2020
R. Riikonen
semanticscholar   +1 more source