Results 31 to 40 of about 14,731 (217)

Hepatic Myelopathy: A Rare Complication of Chronic Liver Failure Treated Conservatively Without Liver Transplantation

Annals of Internal Medicine: Clinical Cases
Hepatic myelopathy (HM) diagnosis requires the exclusion of other causes of spastic paraparesis and typically presents in the setting of recurrent hepatic encephalopathy.
Matthew Lynberg, Ishan Kirti, Nahar Saleh, Haider Naqvi   +3 more
doaj   +1 more source

Brazilian studies on tropical spastic paraparesis: a meta-analysis

Arquivos de Neuro-Psiquiatria, 1994
Tropical spastic paraparesis (TSP) is a chronic progressive myelopathy and in most of the cases has a retroviral (HTLV-1) etiology, when it is denominated HTLV-1 associated-mielopathy (HAM/TSP).
C.M. de Castro Costa, H. Carton, P. Goubau, J.A.C. D'Almeida   +3 more
doaj   +1 more source

Correlating familial Alzheimer’s disease gene mutations with clinical phenotype [PDF]

, 2010
Alzheimer’s disease (AD) causes devastating cognitive impairment and an intense research effort is currently devoted to developing improved treatments for it.
Rossor, M.N., Ryan, N.S.
core   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Upregulation of hsa-miR-125b in HTLV-1 asymptomatic carriers and HTLV-1-associated myelopathy/tropical spastic paraparesis patients

Memorias do Instituto Oswaldo Cruz, 2012
The retrovirus human T lymphotropic virus type 1 (HTLV-1) promotes spastic paraparesis, adult T cell leukaemia and other diseases. Recently, some human microRNAs (miRNAs) have been described as important factors in host-virus interactions.
Larissa Deadame de Figueiredo Nicolete, Roberto Nicolete, Rodrigo Haddad, Rochele Azevedo, Fabíola Attié de Castro, Yuetsu Tanaka, Osvaldo Massaiti Takayanagui, Dimas Tadeu Covas, Simone Kashima   +8 more
doaj   +1 more source

Movement Disorders in Aicardi–Goutières Syndrome and Response to Immunomodulation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This study characterizes movement disorders and treatment responses in seven children with Aicardi–Goutières syndrome (AGS). We retrospectively evaluated motor phenotypes, neuroimaging, and interferon signatures in patients treated with baricitinib or anifrolumab. Spasticity affected all patients, while dystonia was present in 4/7.
Enrique Gonzalez Saez‐Diez, Monica Ferrer Socorro, Kathryn Yang, Nicole Battaglia, Zainab Zaman, Mariko Bennett, Adeline Vanderver, Pui Y. Lee, Lauren A. Henderson, Milena M. Andzelm, Darius Ebrahimi‐Fakhari   +10 more
wiley   +1 more source

Strategies to augment volitional and reflex function may improve locomotor capacity following incomplete spinal cord injury [PDF]

, 2018
Many studies highlight the remarkable plasticity demonstrated by spinal circuits following an incomplete spinal cord injury (SCI). Such plasticity can contribute to improvements in volitional motor recovery, such as walking function, although similar ...
Hornby, T. George, Kim, Hyosub E., Leech, Kristan A.   +2 more
core   +2 more sources

Isolated Corticospinal Tract Lesions as an Early Manifestation of Adrenoleukodystrophy in Children

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Purpose X‐linked adrenoleukodystrophy (ALD) encompasses a wide range of neurological manifestations, classically described as distinct phenotypes including childhood cerebral adrenoleukodystrophy and adult‐onset adrenomyeloneuropathy (AMN).
Elle Winter, Amanda Nagy, Yedda Li, Otto Rapalino, Catherine L. Becker, Joseph Locascio, Camilo Jaimes, Florian Eichler   +7 more
wiley   +1 more source

Novel mutations in the ABCD1 gene caused adrenomyeloneuropathy in the Chinese population

Frontiers in Neurology, 2023
BackgroundAs a rare genetic disease, adrenomyeloneuropathy (AMN) is the most common adult phenotype of X-linked adrenoleukodystrophy (X-ALD). Mutations in the ABCD1 gene have been identified to cause AMN.MethodsWe applied clinical evaluation, laboratory ...
Raoli He, Raoli He, Jian Zhang, Jian Zhang, Tianwen Huang, Tianwen Huang, Guoen Cai, Guoen Cai, Zhangyu Zou, Zhangyu Zou, Qinyong Ye, Qinyong Ye, Qinyong Ye   +12 more
doaj   +1 more source

Exacerbated inflammatory cellular immune response characteristics of HAM/TSP is observed in a large proportion of HTLV-I asymptomatic carriers [PDF]

, 2004
Background A small fraction of Human T cell Leukemia Virus type-1 (HTLV-I) infected subjects develop a severe form of myelopathy. It has been established that patients with HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) show an ...
Silvane Braga Santos, Aurélia Fonseca Porto, André Luiz Muniz, Amélia Ribeiro de Jesus, Elza Magalhães, Ailton Melo, Walderez O Dutra, Kenneth J Gollob, Edgar M Carvalho, B Galvao-Castro, ED Moreira Jr, T Uchiyama, BJ Poiesz, A Gessain, M Osame, H Prince, R Kubota, N Nishimoto, M Osame, S Jacobson, S Jacobson, GP Taylor, S Izumo, JF Kurtzke, A Kramer, M Nagai, E Hanon, N Azimi, R Kubota, M Nagai, EM Carvalho, F Umehara, WE Biddison, JH Richardson, M Popovic, JA Sakai, M Azuma, MP Weekes, JF Giguere, WO Dutra   +39 more
core   +2 more sources