Results 91 to 100 of about 147,177 (327)

Development of a simple mechanical measurement method to measure spasticity based on an analysis of a clinical maneuver and its concurrent validity with the modified Ashworth scale

Frontiers in Bioengineering and Biotechnology, 2022
Background: Despite recent developments in the methodology for measuring spasticity, the discriminative capacity of clinically diagnosed spasticity has not been well established.
Hiroki Tanikawa, Masahiko Mukaino, Shota Itoh, Hikaru Kondoh, Kenta Fujimura, Toshio Teranishi, Kei Ohtsuka, Satoshi Hirano, Hitoshi Kagaya, Eiichi Saitoh, Yohei Otaka   +10 more
doaj   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Functional Brain Correlates of Upper Limb Spasticity and Its Mitigation following Rehabilitation in Chronic Stroke Survivors

Stroke Research and Treatment, 2014
Background. Arm spasticity is a challenge in the care of chronic stroke survivors with motor deficits. In order to advance spasticity treatments, a better understanding of the mechanism of spasticity-related neuroplasticity is needed. Objective.
Svetlana Pundik, Adam D. Falchook, Jessica McCabe, Krisanne Litinas, Janis J. Daly   +4 more
doaj   +1 more source

Kufor-Rakeb syndrome, pallido-pyramidal degeneration with supranuclear upgaze paresis and dementia, maps to 1p36 [PDF]

, 2001
Kufor-Rakeb syndrome is an autosomal recessive nigro-striatal-pallidal-pyramidal neurodegeneration. The onset is in the teenage years with clinical features of Parkinson’s disease plus spasticity, supranuclear upgaze paresis, and dementia.
Al-Din, A., Bond, J., Crow, Y., Hampshire, D.J., Mubaidin, A., Roberts, E., Woods, C.G., Wriekat, A.L.   +7 more
core   +2 more sources

Fabric‐Based Wearable Robotic Exoskeleton Gloves: Advancements and Challenges

Advanced Materials Technologies, EarlyView.
This review highlights interdisciplinary technological advances in fabric‐based robotic gloves, focusing on progress in design, fabrication, actuation, sensing, control, and power and energy requirements. It also addresses performance testing and validation, including biomechanical, strength, functional, user experience, and durability assessments, to ...
Ayse Feyza Yilmaz, Gökhan Ince, Ozgur Atalay   +2 more
wiley   +1 more source

Interventions for improving upper limb function after stroke [PDF]

, 2013
Background: Improving upper limb function is a core element of stroke rehabilitation needed to maximise patient outcomes and reduce disability. Evidence about effects of individual treatment techniques and modalities is synthesised within many reviews ...
Brady, Marian C., Farmer, Sybil E., Langhorne, Peter, Mead, Gillian E., Mehrholz, Jan, Pollock, Alex, van Wijck, Frederike   +6 more
core   +3 more sources

Unilateral Ankle‐Foot Exoneuromusculoskeleton with Balance‐Sensing Feedback for Self‐Help Telerehabilitation after Stroke

Advanced Robotics Research, EarlyView.
This study introduces a hybrid robot that integrates mechanical assistance by musculoskeletons (i.e., soft pneumatic muscle with rigid exoskeletal extensions), neuromuscular electrical stimulation, and vibrotactile feedback in a lightweight wearable mechatronic complex applicable to the paretic ankle–foot poststroke for gait restoration. The system can
Fuqiang Ye, Wei Rong, Waiming Li, Kwok‐Ting Wong, Man‐Kit Pang, Hon‐Wah Wai, Lilly Li, Zicong Hong, Song Guo, Zong‐Hao Ma, Yongping Zheng, Ming Zhang, Nicholas Chow, Jianing Zhang, Xiaoling Hu, Fei Chen, Waisang Poon   +16 more
wiley   +1 more source

Quantitative Ultrasound Imaging to Assess the Biceps Brachii Muscle in Chronic Post-Stroke Spasticity: Preliminary Observation.

Ultrasound in Medicine and Biology, 2018
We prospectively investigated the feasibility of using quantitative ultrasound imaging (QUI) to assess the biceps brachii muscle (BBM) in individuals with chronic post-stroke spasticity.
Jing Gao, Wen He, L. Du, Johnson Chen, David Park, Michael Wells, B. Fowlkes, M. O'Dell   +7 more
semanticscholar   +1 more source

CypD Dependent mPTP Opening Is Crucial for Oxidized Mitochondrial DNA Release in Ferroptosis

Advanced Science, EarlyView.
Ferroptosis is driven by mitochondrial permeability transition pore (mPTP) opening, which induces mitochondrial swelling and releases oxidized mitochondrial DNA. The released mtDNA activates cGAS–STING signaling, promotes ferritinophagy, and amplifies ferroptotic cell death. Disruption of mtDNA repair sensitizes tumors to ferroptosis in vivo, revealing
Hong Zhou, Wan Fu, Shizuo Liu, Zili Zhang, Hanyan Luo, Qing Zhong   +5 more
wiley   +1 more source

The Adverse Effect of Spasticity on 3-Month Poststroke Outcome Using a Population-Based Model

Stroke Research and Treatment, 2014
Several devices and medications have been used to address poststroke spasticity. Yet, spasticity’s impact on outcomes remains controversial. Using data from a cohort of 460 ischemic stroke patients, we previously published a validated multivariable ...
S. R. Belagaje, C. Lindsell, C. J. Moomaw, K. Alwell, M. L. Flaherty, D. Woo, K. Dunning, P. Khatri, O. Adeoye, D. Kleindorfer, J. Broderick, B. Kissela   +11 more
doaj   +1 more source