Results 141 to 150 of about 147,177 (327)

Lennox–Gastaut syndrome in a patient with biallelic TELO2 variants

Epileptic Disorders, EarlyView.
Melissa Odabassian, Kenneth A. Myers
wiley   +1 more source

MDSGene Systematic Review of Common Forms of Dominant Hereditary Spastic Paraplegia: Novel Insights

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Hereditary spastic paraplegia (HSP) is a neurodegenerative disorder characterized by progressive spasticity and lower limb weakness. The most common forms of autosomal dominant HSP are caused by pathogenic variants in SPAST (SPG4 or HSP‐SPAST), ATL1 (SPG3A or HSP‐ATL1), and REEP1 (SPG31 or HSP‐REEP1).
Ce Kang, Rajasumi Rajalingam, Zachary Walls, Jana Huang, Christine Sun, Laura I. Rudaks, Dennis Yeow, Ashar Rasheed, Jenny W. Zhang, Moath Hamed, Marianthi Breza, Susen Schaake, Chetan Vekhande, Jason Massa, Robyn E. Massa, Aakash Shetty, Carolyn M. Sue, Franca Cambi, Oksana Suchowersky, Franca Vulinovic, Sonja Petkovic, Christine Klein, Katja Lohmann, Connie Marras, Kishore R. Kumar   +24 more
wiley   +1 more source

Percutaneous Cryoneurolysis as a Dynamic Treatment for Spasticity: A Case Series

Archives of Rehabilitation Research and Clinical Translation
: Spasticity, whether from stroke or spinal cord injury or other causes, remains challenging to treat effectively. Common spasticity treatments such as stretching, physical therapy, injection therapy, and even surgery may not result in optimal or the ...
Clay C. Guynn, DO
doaj   +1 more source

Interrater reliability of a modified Ashworth scale of muscle spasticity.

Physical Therapy, 1987
Richard W. Bohannon, M. B. Smith
semanticscholar   +1 more source

From mechanism to phenotype: What fits in a basket trial

Epilepsia, EarlyView.
Kette D. Valente
wiley   +1 more source

Loss‐of‐Function Variants in CPT1C: No Support for a Causal Role in Hereditary Spastic Paraplegia

Movement Disorders, EarlyView.
Abstract Background Hereditary spastic paraplegias (HSPs) are neurodegenerative disorders characterized by lower‐limb spasticity. Pathogenic variants in CPT1C have been implicated in HSP. Objective The objective of this study was to assess whether CPT1C loss‐of‐function (LOF) variants are causally associated with HSP.
Rui Zhu, Lang Liu, Mehrdad A. Estiar, Farnaz Asayesh, Jamil Ahmad, Meron Teferra, Grace Yoon, Mark Tarnopolsky, Kym M. Boycott, Nicolas Dupre, Patrick A. Dion, Oksana Suchowersky, Albena Jordanova, Yi‐Chung Lee, Giovanni Stevanin, Stephan Zuchner, Guy A. Rouleau, Ziv Gan‐Or   +17 more
wiley   +1 more source

Feedback control of unsupported standing in paraplegia. Part I: optimal control approach [PDF]

, 1997
This is the first of a pair of papers which describe an investigation into the feasibility of providing artificial balance to paraplegics using electrical stimulation of the paralyzed muscles. By bracing the body above the shanks, only stimulation of the
Donaldson, N., Hunt, K.J., Munih, M.
core  

The Cerebellar Cognitive‐Affective Syndrome Scale Reveals Consistent, Early, and Progressive Neuropsychological Deficits in Autosomal‐Recessive Spastic Ataxia of Charlevoix‐Saguenay: A Large International Cross‐Sectional Study

Movement Disorders, EarlyView.
Abstract Background Neuropsychological deficits have been observed in patients with cerebellar damage, but never thoroughly investigated in autosomal recessive spastic ataxia of Charlevoix‐Saguenay (ARSACS). Objectives The goal is the characterization of presence, severity, and profile of neuropsychological deficits in ARSACS using the cerebellar ...
Julie Fortin, Matthis Synofzik, Élyse‐Anne Pedneault‐Tremblay, Dominik Hermle, Andreas Thieme, Dagmar Timmann, Roberta La Piana, Bernard Brais, Justine Dolbec, Isabelle Côté, Cynthia Gagnon, Andreas Traschütz   +11 more
wiley   +1 more source

The neuropharmacology of baclofen [PDF]

, 1988
AI Shapovalov, B Ault, B Ault, B Ault, B Ault, B Ault, B Sutor, B Sutor, BH Gähwiler, BH Gähwiler, BW Connors, CF Terrence, CG Swahn, CN Scholfield, CR Cain, D Stevens, DR Curtis, DR Curtis, DR Curtis, DR Gehlert, DR Hill, E Cherubini, E Knutsson, E Mugnaini, E Roberts, E Schlicker, EW Karbon, FK Pierau, FK Pierau, GAR Johnston, GE Fagg, GGS Collins, GP Wilkin, GW Price, H Fukuda, H Keberle, H Möhler, H Ono, HJ Bein, HL Haas, HR Olpe, HR Olpe, HR Olpe, J Davies, J Davies, J Davies, J Swaynok, JJ Dreifuss, JL Henry, JL Henry, JL Henry, JR Bianchine, JR Howe, JW Phillis, K Dunlap, K Koketsu, K Krnjevic, KJ Fotherby, KS Saito, M Desarmenien, M Fillenz, M Inoue, M Inoue, M Kato, MA Simmonds, MR Klee, N Auden, N Ogata, NG Bowery, NG Bowery, NG Bowery, NG Bowery, NR Newberry, NR Newberry, NR Newberry, P Ashby, P Krogsgaard-Larsen, P Polc, PR Wilson, R Benecke, R Capek, RA Davidoff, RD Pinnock, RF Schmidt, RH Evans, RJ Brady, RR Young, RW Birkmayer, S Fox, SJ Enna, SJ Potashner, SJ Potashner, SR Barry, SR Zukin, TH Lanthorn, TJ Blaxter, U Heinemann, U Misgeld, V Ben-Ari, W Haefely, W Haefely, W Laskey, W Laskey, W Zieglgänsberger, WJ Wojcik   +104 more
core   +1 more source

Increased Lower Limb Spasticity but Not Strength or Function Following a Single-Dose Serotonin Reuptake Inhibitor in Chronic Stroke [PDF]

, 2015
Objective: To investigate the effects of single doses of a selective serotonin reuptake inhibitor (SSRI) on lower limb voluntary and reflex function in individuals with chronic stroke. Design: Double-blind, randomized, placebo-controlled crossover trial.
Gourab, Krishnaj, Hornby, T. George, Schmit, Brian D.   +2 more
core   +1 more source