Results 241 to 250 of about 147,177 (327)

Pharmacological management of spasticity in multiple sclerosis: Systematic review and consensus paper

Multiple Sclerosis, 2016
S. Otero-Romero, J. Sastre-Garriga, G. Comi, H. Hartung, P. Soelberg Sørensen, A. Thompson, P. Vermersch, R. Gold, X. Montalban   +8 more
semanticscholar   +1 more source

Infantile‐Onset Ascending Hereditary Spastic Paraplegia due to a Homozygous ALS2 Exons 24–25 Deletion: Expanding the Genotypic Spectrum

American Journal of Medical Genetics Part A, Volume 200, Issue 4, Page 929-936, April 2026.
ABSTRACT We describe a novel homozygous intragenic deletion in the ALS2 gene in an 8‐year‐old boy with Infantile‐onset Ascending Hereditary Spastic Paraplegia (IAHSP) and oculomotor apraxia, thereby contributing to the expanding genetic landscape of ALS2‐related disorders.
Vito Luigi Colona, Maria Gnazzo, Silvia Genovese, Gessica Vasco, Lorena Travaglini, Maurizio Sabbadini, Marina Macchiaiolo, Francesco Nicita, Jacopo Sartorelli, Carmelo Piscopo, Enrico Castelli, Enrico Bertini, Andrea Bartuli, Antonio Novelli, Gessica Della Bella, Davide Vecchio   +15 more
wiley   +1 more source

Leading across boundaries: establishment of the UCLH community outreach intrathecal baclofen refill service. [PDF]

BMJ Open Qual
Keenan E, Ang K, Lee H, Betteridge N, Chal D, O'Connell R, Buchanan K, Stevenson V.   +7 more
europepmc   +1 more source

Who Needs Endoscopic Removal of Food Residue From the Esophagus Before Peroral Endoscopic Myotomy for Esophageal Achalasia and Esophagogastric Junction Outflow Obstruction?

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Objectives Peroral endoscopic myotomy (POEM) is an established treatment for esophageal achalasia. Despite favorable outcomes, the risk of reflux aspiration during general anesthesia induction in POEM remains a concern. This study aimed to identify the risk factors for food residue in the esophagus before POEM and evaluate the necessity of ...
Masatoshi Kaizuka, Tetsuya Tatsuta, Yohei Sawada, Taka Asari, Shiro Hayamizu, Shinji Oota, Keisuke Hasui, Hidezumi Kikuchi, Hiroto Hiraga, Daisuke Chinda, Tatsuya Mikami, Shinsaku Fukuda, Hirotake Sakuraba   +12 more
wiley   +1 more source

Botulinum toxin A for post-stroke spasticity: Insights from the French National Hospital Discharge Database (2015-2023). [PDF]

Eur Stroke J
Bensmail D, Forestier A, Loze JY, Karam P.   +3 more
europepmc   +1 more source

Is Single‐Session Peroral Endoscopic Myotomy With Fundoplication Safe and Effective in Achalasia? A Systematic Review and Meta‐Analysis

DEN Open, Volume 6, Issue 1, April 2026.
This meta‐analysis of nine studies (202 patients) demonstrates that peroral endoscopic myotomy with fundoplication (POEM‐F) achieves a technical success of 94.8% and significant symptom improvement (Eckardt score reduction from 8.3 to 1.1). Post‐procedural esophagitis occurred in 20.7% and wrap integrity was preserved in 75.7% on follow‐up, supporting ...
Yusuf Kagzi, Abuzar Asif, Srinivas Reddy Puli   +2 more
wiley   +1 more source

A proof-of-concept study on the effectiveness of botulinum toxin on spasticity plus syndrome in multiple sclerosis. [PDF]

Neurol Sci
Moccia M, Clemente C, Braca S, Carotenuto A, Petracca M, Iodice R, Lanzillo R, Brescia Morra V.   +7 more
europepmc   +1 more source

EAES Clinical Practice Guideline 2026 Protocol: Multi‐Society Recommendations for the Treatment of Achalasia

Clinical and Public Health Guidelines, Volume 3, Issue 2, April 2026.
ABSTRACT Introduction Achalasia causes significant distress and quality‐of‐life impairment to patients. Several options exist for the treatment of achalasia including endoscopic [intra‐sphincteric injection of botulinum toxin, pneumatic dilation, peroral endoscopic myotomy (POEM)], and surgical techniques such as Heller Myotomy.
Bright Huo, Aaron J. Yu, Milos Bjelovic, Sofia Tsokani, Stephanie Sanger, Dimitris Mavridis, Gordon Guyatt, Stavros A. Antoniou   +7 more
wiley   +1 more source

Impact of Early Versus Late Treatment with Botulinum Toxin A on Goal Attainment in Post-Stroke Spasticity: A Retrospective Cohort Study. [PDF]

Toxins (Basel)
Patel A, Zhang J, Page S, Harding S, Beneteau M, Navickas C, Esquenazi A.   +6 more
europepmc   +1 more source

Long‐term child outcomes after prenatal aspirin exposure: A 4‐year follow‐up of a randomized controlled trial (the APRIL study)

International Journal of Gynecology &Obstetrics, Volume 173, Issue 1, Page 302-311, April 2026.
Abstract Objective To identify the long‐term child outcomes after prenatal aspirin exposure. Methods This study is a follow‐up of a randomized controlled trial (RCT) evaluating low‐dose aspirin in the prevention of recurrent spontaneous preterm labor (the APRIL study) comparing aspirin 80 mg daily (n = 194) to placebo (n = 193) in singletons.
Emilie V. J. van Limburg Stirum, Janneke van ’t Hooft, Anadeijda J. E. M. C. Landman, Martijn J. J. Finken, Anita C. J. Ravelli, Aleid G. Leemhuis, Eva Pajkrt, Martijn A. Oudijk, Marjon A. de Boer   +8 more
wiley   +1 more source