Results 71 to 80 of about 629,807 (310)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Spatial navigation ability is associated with the assessment of smoothness of driving during changing lanes in older drivers [PDF]

, 2020
Masafumi Kunishige, Hideki Miyaguchi, Hiroshi Fukuda, Tadayuki Iida, Nami Kawabata, Chinami Ishizuki   +5 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

knots geometry and its training in school [PDF]

Fanāvarī-i āmūzish, 2007
Euclidean geometry has been taught to students in schools for many years. Topological structures are among the topics that have not received much attention in school geometry.
E. Reyhani
doaj  

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

ASSESSMENT AND IMPROVEMENT OF SPATIAL ABILITY DEVELOPED BY GRAPHICAL SUBJECTS

Journal of Industrial Design and Engineering Graphics, 2019
The ability to mentally manipulate 2D and 3D figures is defined as spatial visualization ability and can be measured with simple cognitive tests such as Mental Rotation Test and Mental Cutting Test.
Georgiana CORSIUC, Carmen MARZA, Ana-Maria GRAUR   +2 more
doaj  

Towards Personally Relevant Navigation: The Differential Effects of Cognitive Style and Map Orientation on Spatial Knowledge Development

Applied Sciences
Under emergencies such as floods and fires or during indoor navigation where cues from local landmarks and a Global Positioning System (GPS) are no longer available, the acquisition of comprehensive environmental representation becomes particularly ...
Hannah Park, Manish K. Dixit, Fatemeh Pariafsai   +2 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Profile of Spatial Ability of High School Students when Solving Geometry Problems

Southeast Asian Mathematics Education Journal
Learning geometry began in elementary school and continued through high school, as well as at more advanced levels in the area of interest of higher education.
Septia Wahyuni, Julia Noviani, Dian Saleha   +2 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source