Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Investigating accessibility indicators for feedback from a travel to a land use model [PDF]
Activity locations such as work locations or leisure facilities are not uniformly distributed geographically. Also, the travel access to different locations is not uniform.
Thomas Nicolai, Kai Nagel
core
Measuring and optimizing spatial accessibility to emergency medical services with a focus on age-based spatial variations in EMS risk. [PDF]
Front Public HealthLuo W, Chen X, Zhao L, He L.
europepmc +1 more source
Synchronized locomotion can improve spatial accessibility inside ant colonies. [PDF]
Proc Biol Sci, 2023 Doering GN, Lee CL, Dalnoki-Veress K.
europepmc +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Unemployment duration, city size, and the tightness of the labor market
This paper attempts to determine whether residential location affects unemployment duration. Our analysis is based on a spatial job search framework that shows the importance of dissociating the role of travel time from physical distance in unemployment ...
Carl Gaigné, Cécile Détang-Dessendre
core +1 more source
A structured approach to promote equity in spatial accessibility to TB services during private sector engagement. [PDF]
IJTLD OpenXiong Y +9 more
europepmc +1 more source
Hide Your Distance: Privacy Risks and Protection in Spatial Accessibility Analysis. [PDF]
Proc ACM SIGSPATIAL Int Conf Adv Inf, 2023 Fan L, Bonomi L.
europepmc +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
[Spatial accessibility and optimization of pediatric healthcare resources in Beijing]. [PDF]
Beijing Da Xue Xue Bao Yi Xue BanZhang J, Zhu Z, Gong C, Han R, Yang L.
europepmc +1 more source