Results 71 to 80 of about 12,748 (218)
BuildingsEducational buildings are characterized by daily movement and continuous interaction between formal and informal learning spaces. Understanding how students navigate and occupy these environments and how these experiences affect their academic ...
Jamil Binabid
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Photoreceptor Regulation of Spatial Visual Behavior
Investigative Opthalmology & Visual Science, 2015 To better understand how photoreceptors and their circuits support luminance-dependent spatial visual behavior.Grating thresholds for optokinetic tracking were measured under defined luminance conditions in mice with genetic alterations of photoreceptor activity.The luminance conditions that enable cone- and rod-mediated behavior, and the luminance ...
Nazia M, Alam +4 more
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Conduct in spatial markets: An empirical analysis of spatial pricing behavior
Papers in Regional Science, 1992 An empirical procedure for differentiating between organized and competitive spatial oligopoly (or oligopsony) is proposed. The procedure evaluates pricing behavior using a time series of short-term price data from spatially dispersed locations. Cooperation is implied when price changes at one location are matched instantly at others.
Bruce L. Benson +2 more
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Individual Behavior Simulation Based on Grid Object and Agent Model
ISPRS International Journal of Geo-Information, 2019 For the simplicity of spatial modeling in Cellular Automaton (CA) and the complexity of vector spatial expression in the Multi-Agent System (MAS), the concept of grid object as the spatial model of individual behavior simulation was proposed with spatial
Yiquan Song, Lei Niu, Yi Li
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FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Transformation of spatial representations along hippocampal circuits
iScienceSummary: The hippocampus is thought to provide the brain with a cognitive map of the external world by processing various types of spatial information.
Bérénice Gandit +6 more
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source