Results 71 to 80 of about 589,072 (264)

Comparing the paths of Hedgehog release in artificial and natural settings

open access: yesFEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Photoreceptor Regulation of Spatial Visual Behavior

open access: yesInvestigative Opthalmology & Visual Science, 2015
To better understand how photoreceptors and their circuits support luminance-dependent spatial visual behavior.Grating thresholds for optokinetic tracking were measured under defined luminance conditions in mice with genetic alterations of photoreceptor activity.The luminance conditions that enable cone- and rod-mediated behavior, and the luminance ...
Nazia M, Alam   +4 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

From motion to meaning: understanding students’ seating preferences in libraries through PIR-enabled machine learning and explainable AI

open access: yesFrontiers in Psychology
This study presents a comprehensive, data-driven investigation into students’ seating preferences within academic library environments, aiming to inform user-centered spatial design.
Gizem Izmir Tunahan   +2 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Conduct in spatial markets: An empirical analysis of spatial pricing behavior

open access: yesPapers in Regional Science, 1992
An empirical procedure for differentiating between organized and competitive spatial oligopoly (or oligopsony) is proposed. The procedure evaluates pricing behavior using a time series of short-term price data from spatially dispersed locations. Cooperation is implied when price changes at one location are matched instantly at others.
Bruce L. Benson   +2 more
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Spatial Behavior and Academic Performance Among Architecture Students: A Gender-Based Comparative Study

open access: yesBuildings
Educational buildings are characterized by daily movement and continuous interaction between formal and informal learning spaces. Understanding how students navigate and occupy these environments and how these experiences affect their academic ...
Jamil Binabid
doaj   +1 more source

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