Results 61 to 70 of about 1,951,035 (294)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Influence of Air Quality on Pro-environmental Behavior of Chinese Residents: From the Perspective of Spatial Distance

Frontiers in Psychology, 2020
Although environmental issues have attracted public attention, there are still many people unwilling to make behavioral changes to solve the problem, which makes promoting pro-environmental behavior become an interesting research topic.
Guanghua Sheng, Jiatong Dai, Hong Pan
doaj   +1 more source

Lessons from Non-Abelian Plasma Instabilities in Two Spatial Dimensions

, 2007
Plasma instabilities can play a fundamental role in quark-gluon plasma equilibration in the high energy (weak coupling) limit. Early simulations of the evolution of plasma instabilities in non-abelian gauge theory, performed in one spatial dimension ...
O. P. Pavlenko, O. P. Pavlenko, Peter Arnold, Po-Shan Leang, Y. E. Pokrovsky, Y. E. Pokrovsky, Y. E. Pokrovsky, Y. E. Pokrovsky, Y. E. Pokrovsky, Y. E. Pokrovsky   +9 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A spatial model of mosquito host-seeking behavior. [PDF]

PLoS Computational Biology, 2012
Mosquito host-seeking behavior and heterogeneity in host distribution are important factors in predicting the transmission dynamics of mosquito-borne infections such as dengue fever, malaria, chikungunya, and West Nile virus. We develop and analyze a new
Bree Cummins, Ricardo Cortez, Ivo M Foppa, Justin Walbeck, James M Hyman   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Radiative multipole moments of integer-spin fields in curved spacetime [PDF]

, 1997
Radiative multipole moments of scalar, electromagnetic, and linearized gravitational fields in Schwarzschild spacetime are computed to third order in v in a weak-field, slow-motion approximation, where v is a characteristic velocity associated with the ...
A. Abramovici, B. S. DeWitt, C. Bradaschia, C. Cutler, C. Cutler, C. M. Will, C. Morette DeWitt, C.W. Misner, D. W. Sciama, E. Poisson, E. Poisson, E. Poisson, E. W. Leaver, Eric Poisson, I.S. Gradshteyn, J. Carminati, J. Hadamard, J. N. Goldberg, J.L. Synge, K. S. Thorne, K. S. Thorne, L. Blanchet, L. Blanchet, L. Blanchet, L. E. Kidder, M. Sasaki, M. Shibata, R. G. McLenaghan, R. G. McLenaghan, R. H. Price, S. A. Teukolsky, S. Chandrasekhar, S. Chandrasekhar, S. Mano, Stephen W. Leonard, W. B. Bonnor, W. E. Couch, W. G. Anderson, W. Kundt, Y. Fourès-Bruhat, Y. Mino   +40 more
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source