Results 81 to 90 of about 1,951,035 (294)

Escape rate of an active Brownian particle over a potential barrier

, 2012
We study the dynamics of an active Brownian particle with a nonlinear friction function located in a spatial cubic potential. For strong but finite damping, the escape rate of the particle over the spatial potential barrier shows a nonmonotonic ...
Burada, P. S., Lindner, B.
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

From motion to meaning: understanding students’ seating preferences in libraries through PIR-enabled machine learning and explainable AI

Frontiers in Psychology
This study presents a comprehensive, data-driven investigation into students’ seating preferences within academic library environments, aiming to inform user-centered spatial design.
Gizem Izmir Tunahan, Goksu Tuysuzoglu, Hector Altamirano   +2 more
doaj   +1 more source

k-nearest neighbors prediction and classification for spatial data

, 2018
We propose a nonparametric predictor and a supervised classification based on the regression function estimate of a spatial real variable using k-nearest neighbors method (k-NN). Under some assumptions, we establish almost complete or sure convergence of
Ahmed, Mohamed-Salem, Attouch, Mohammed Kadi, Dabo-Niang, Sophie, N'diaye, Mamadou   +3 more
core   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Individual Behavior Simulation Based on Grid Object and Agent Model

ISPRS International Journal of Geo-Information, 2019
For the simplicity of spatial modeling in Cellular Automaton (CA) and the complexity of vector spatial expression in the Multi-Agent System (MAS), the concept of grid object as the spatial model of individual behavior simulation was proposed with spatial
Yiquan Song, Lei Niu, Yi Li
doaj   +1 more source

Fragmentation with a Steady Source

, 2000
We investigate fragmentation processes with a steady input of fragments. We find that the size distribution approaches a stationary form which exhibits a power law divergence in the small size limit, P(x) ~ x^{-3}. This algebraic behavior is robust as it
Austin, Barabási, Ben-Naim, Boyer, Charlesby, Chase, Cheng, E. Ben-Naim, Filippov, Grady, Ishii, Krapivsky, Krapivsky, Lahererre, Montroll, Oddershede, P.L. Krapivsky, Rao, Redner, Rodgers, Shinnar, Tarjus, Ziff, Ziff   +23 more
core   +1 more source