Results 81 to 90 of about 304,521 (259)

Spatial complexity method for tracking brain development and degeneration using functional near-infrared spectroscopy. [PDF]

Biomed Opt Express, 2022
Liang Z, Wang Y, Tian H, Gu Y, Arimitsu T, Takahashi T, Minagawa Y, Niu H, Tong Y.   +8 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Population agglomeration is a harbinger of the spatial complexity of COVID-19. [PDF]

Chem Eng J, 2021
Geng X, Gerges F, Katul GG, Bou-Zeid E, Nassif H, Boufadel MC.   +5 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Spatial and Chemical Complexity in the W75N Star-forming Region

The Astrophysical Journal
We present the analysis of NOEMA interferometric observations of the high-mass star-forming region W75N(B) with a focus on molecular composition and distribution of prebiotic molecules in the source’s multiple cores.
Morgan M. Giese, Will E. Thompson, Dariusz C. Lis, Susanna L. Widicus Weaver   +3 more
doaj   +1 more source

Analyzing and Discovering Spatial Algorithm Complexity Vulnerabilities in Recursion

Applied Sciences
The algorithmic complexity vulnerability (ACV) that may lead to denial of service attacks greatly disrupts the security and availability of applications, and due to the widespread use of third-party libraries, its impact may be amplified through the ...
Ziqi Wang, Debao Bu, Weihan Tian, Baojiang Cui   +3 more
doaj   +1 more source

Action Video Gaming Experience Related to Altered Resting-State EEG Temporal and Spatial Complexity. [PDF]

Front Hum Neurosci, 2021
Cui R, Jiang J, Zeng L, Jiang L, Xia Z, Dong L, Gong D, Yan G, Ma W, Yao D.   +9 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source