Results 41 to 50 of about 190,335 (293)

Mekân Dizimi: Mekânsal Örgütlenmeyi Grafikleştirme, Sayısallaştırma, Okuma ve Yorumlama

PLANARCH - Design and Planning Research
Mekân dizimi, mekânsal örgütlenmeler arasındaki benzerlik ya da farklılıkları analiz etmek için kullanılan bir yöntemdir. Bu çalışma, bu yöntemin kullanımına ilişkin detayları bir uygulama üzerinden ortaya çıkarmayı amaçlamaktadır.
Ayhan Bekleyen
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

On symmetric spatial configurations

Discrete Mathematics, 1994
The paper is concerned with symmetric 2-configurations \((v_ k)_ 2\) consisting of \(v\) points and \(v\) lines, \(k\) points on a line and \(k\) lines through a point, 2 lines have at most 2 points in common and 2 points are connected by at most 2 lines.
openaire   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Assessing the spatial equity of the aged care institutions based on the improved potential model: a case study in Shanghai, China

Frontiers in Public Health
With the spread of an aging society, the demand for aged care institutions among older adults is increasing. The inadequate supply and distribution of aged care institutions have led to an increasing concern about spatial equity in aged care institutions.
Chenyang Wang, Xiuli Geng, Xiuli Geng
doaj   +1 more source

SPACE SYNTAX ANALYSES IN DEFINING THE CONNECTION OF DEVELOPMENT CENTERS IN BALIKPAPAN

Dimensi: Journal of Architecture and Built Environment, 2021
Old town means an historic or original core of a city which signifies the city’s origin growth. When the city develops and expands its built area, the emergence of a new development center will be inevitable.
Sherlia, Nadia Almira Jordan, Elin Dyah Syafitri   +2 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source