Results 101 to 110 of about 11,399,518 (374)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Recover Fine-Grained Spatial Data from Coarse Aggregation

, 2017
In this paper, we study a new type of spatial sparse recovery problem, that is to infer the fine-grained spatial distribution of certain density data in a region only based on the aggregate observations recorded for each of its subregions.
Kong, Linglong, Liu, Bang, Mavrin, Borislav, Niu, Di   +3 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

The spatial distribution of star and cluster formation in M51

, 2008
Aims. We study the connection between spatially resolved star formation and young star clusters across the disc of M51. Methods. We combine star cluster data based on B, V, and I-band Hubble Space Telescope ACS imaging, together with new WFPC2 U-band ...
Alvensleben, Alvensleben, Alvensleven, Alvensleven, Bash, Bastian, Bastian, Bastian, Bastian, Bate, Beech, Bertelli, Bertin, Bik, Boeshaar, Cardelli, Charbonnel, Condon, Contopoulos, Contopoulos, de Grijs, de Grijs, Diaz, Dolphin, Efremov, Efremov, Elmegreen, Elmegreen, Elmegreen, Elmegreen, Elmegreen, Elson, Fall, Feldmeier, García-Burillo, Gieles, Gieles, Girardi, Gomez, Goodwin, H. J. G. L. M. Lamers, Helou, Hill, Holtzman, Hunter, Hwang, Jarrett, Kennicutt, Kennicutt, Kennicutt, Kennicutt, Kennicutt, Kroupa, Lada, Larsen, Larsen, Larsen, Larsen, Larson, Marsh, Meurer, Mihos, Murgia, Murphy, Murphy, Niklas, Niklas, P. Anders, Patrikeev, R. A. Scheepmaker, Roberts, S. S. Larsen, Schaerer, Scheepmaker, Schlegel, Schuster, Tamburro, Tully, Whitmore, Whitmore, Yun, Zhang, Zimmer   +82 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Spatial distribution of Cherenkov radiation in periodic dielectric media

, 2009
The nontrivial dispersion relation of a periodic medium affects both the spectral and the spatial distribution of Cherenkov radiation. We present a theory of the spatial distribution of Cherenkov radiation in the far-field zone inside arbitrary three ...
Bykov V P, Cherenkov P A, Christian Kremers, Dmitry N Chigrin, Jeffrey A, Jelley J V, Joannopoulos J D, Sakoda K, Taflove A   +8 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

POPULATION STRUCTURE OF Heteropsis spp. Kunth (TITICA VINE) IN THE TAPAJÓS NATIONAL FOREST, PARÁ-BRAZIL [PDF]

Revista Árvore
The objective of the present study was to analyze the ecological aspects of Heteropsis spp. Kunth (titica vine) in an area maintained under forest management conditions.
Lizandra Elizeário dos Santos, João Ricardo Vasconcellos Gama, Andrea Araújo da Silva, Marcela Gomes da Silva   +3 more
doaj   +2 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source