Results 111 to 120 of about 4,411,385 (345)

Dynamics of Adaptation in Spatially Heterogeneous Metapopulations

PLoS ONE, 2013
The selection pressure experienced by organisms often varies across the species range. It is hence crucial to characterise the link between environmental spatial heterogeneity and the adaptive dynamics of species or populations. We address this issue by studying the phenotypic evolution of a spatial metapopulation using an adaptive dynamics approach ...
Papaïx, Julien, David, Olivier, Lannou, Christian, Monod, Herve   +3 more
openaire   +7 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Intratumoral Spatial Heterogeneity at Perfusion MR Imaging Predicts Recurrence-free Survival in Locally Advanced Breast Cancer Treated with Neoadjuvant Chemotherapy.

Radiology, 2018
Purpose To characterize intratumoral spatial heterogeneity at perfusion magnetic resonance (MR) imaging and investigate intratumoral heterogeneity as a predictor of recurrence-free survival (RFS) in breast cancer.
Jia Wu, G. Cao, Xiaoli Sun, Juheon Lee, D. Rubin, S. Napel, A. Kurian, B. Daniel, Ruijiang Li   +8 more
semanticscholar   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Rainfall-Induced landslide susceptibility prediction considering spatial heterogeneity

Earthquake Research Advances
Existing landslide susceptibility prediction methods often fail to fully account for the spatial heterogeneity of environmental factors such as topography, soil, and vegetation, nor do they accurately reflect the impact of extreme rainfall on landslide ...
Xingfu Zhang, Abi Erdi
doaj   +3 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Spatial heterogeneity promotes coexistence of rock-paper-scissor metacommunities

, 2012
The rock-paper-scissor game -- which is characterized by three strategies R,P,S, satisfying the non-transitive relations S excludes P, P excludes R, and R excludes S -- serves as a simple prototype for studying more complex non-transitive systems.
Allesina, Amarasekare, Axelrod, Axelrod, Benaïm, Boerlijst, Bresch, Buss, Cameron, Cantrell, Durrett, Durrett, Durrett, Durrett, Eigen, Frean, Gravel, Hamilton, Hanski, Hastings, Hauert, Hauert, Hofbauer, Hofbauer, Hofbauer, Hofbauer, Holland, Ifti, Iwasa, Karolyi, Kerr, Killingback, Kirkland, Kirkup, Krupa, Lankau, Levin, May, Maynard Smith, Maynard Smith, Maynard-Smith, Moquet, Nahum, Nakamaru, Nakamaru, Nowak, Ohtsuki, Paquin, Parker, Reichenbach, Roelke, Rojas-Echenique, Santos, Schreiber, Schreiber, Schreiber, Schreiber, Schreiber, Schöfisch, Sebastian J. Schreiber, Sinervo, Szabó, Tainaka, Timothy P. Killingback, Vandermeer, Vandermeer, Vandermeer   +66 more
core   +1 more source

Analysis of Metro Station Ridership Considering Spatial Heterogeneity

Chinese Geographical Science, 2019
This study aims to explore the role of spatial heterogeneity in ridership analysis and examine the relationship between built environment, station attributes and urban rapid transit ridership at the station level.
Zuoxian Gan, T. Feng, Min Yang, H. Timmermans, Jinyu Luo   +4 more
semanticscholar   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source