Results 91 to 100 of about 3,162,655 (261)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Self-employment in Brazil and its determinants: a spatial analysis [PDF]
In this paper, we intend to identify some factors underlying the different rates of participation of self-employed workers in Brazilian municipalities. In contrast with previous analysis, our study is sensitive to the spatial dimension of self-employment
Flavia Chein +2 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Spatial heterogeneity in the urban household living conditions: A-GIS-based spatial analysis
Annals of GISThe unplanned urban expansion and extreme population pressure have caused several bottlenecks for city dwellers, which have been reflected in the form of inter-urban spatial inequality in living conditions at the household level.
Subham Roy +3 more
doaj +1 more source
BMC Medical Research Methodology, 2019 Background In the context of environmentally influenced communicable diseases, proximity to environmental sources results in spatial heterogeneity of risk, which is sometimes difficult to measure in the field.
Abdoulaye Guindo +10 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
important is access to employment offices in Spain? An urban and non-urban perspective [PDF]
Investigaciones Regionales - Journal of Regional Research, 2011 The aim of this paper is to analyze the effect of the accessibility to employment offices on local unemployment rates according to the distribution of three different types of municipalities: large urban, small urban and non-urban.
Patricia Suárez Cano +2 more
doaj
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Single-cell and spatial omics: exploring hypothalamic heterogeneity
Neural Regeneration ResearchElucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions.
Muhammad Junaid +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source