Results 91 to 100 of about 4,411,385 (345)

Spatial Heterogeneity of Vegetation Structure, Plant N Pools and Soil N Content in Relation to Grassland Management

Agronomy, 2020
Spatial heterogeneity in plant and soil properties plays a key role for biogeochemical cycling, nutrient losses and ecosystem function. Different management practices are expected to induce varying levels of spatial heterogeneity in agroecosystems, but ...
Juliette M. G. Bloor, Antoine Tardif, Julien Pottier   +2 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Spatial heterogeneity patterns along the human footprint gradient and their ecological implications: A case study in South Korea

Ecological Indicators
Assessing spatial heterogeneity patterns along human footprint (HF) gradients is important for understanding biodiversity conservation in human-modified landscapes.
Kyoung-Ho Kim, Minkyu Park, Taeho Park, Donghae Baek, Gyobeom Kim, Namjoo Heo, Dong Jun Chun   +6 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Determination of intertidal macroalgae community patterns using the power law model.

PLoS ONE, 2022
The spatial heterogeneity of macroalgae in intertidal zones affects the stability of marine ecosystem communities, contributes to the maintenance of coastal biodiversity, and has an essential role in ecosystem and habitat maintenance.
Xunmeng Li, Jianqu Chen, Jun Li, Kai Wang, Zhenhua Wang, Shouyu Zhang   +5 more
doaj   +1 more source

Noise from spatial heterogeneity changes signal amplification magnitude and increases the variability in dose responses [PDF]

, 2008
In most molecular level simulations, spatial heterogeneity is neglected by the well-mixed condition assumption. However, the signals of biomolecular networks are affected from both time and space, which are responsible for diverse physiological ...
Heslop-Harrison, P., Kim, J., Mao, X.
core  

Mathematical Modelling of Mosquito Dispersal in a Heterogeneous Environment. [PDF]

, 2012
Mosquito dispersal is a key behavioural factor that affects the persistence and resurgence of several vector-borne diseases. Spatial heterogeneity of mosquito resources, such as hosts and breeding sites, affects mosquito dispersal behaviour and ...
Alonso, Angelina Mageni Lutambi, Arino, Arino, Bayoh, Beier, Blower, Britch, Britch, Cano, Cariboni, Chitnis, Chitnis, Clarke, Cummins, Depinay, Gething, Gu, Hay, Hoare, Jeefoo, Jin, Keeling, Killeen, Kirby, Knols, Le Menach, Le Menach, Li, Li, Manga, Martens, Meinsma, Melissa A. Penny, Midega, Minakawa, Mwandawiro, Nakul Chitnis, Ngwa, Nourridine, Okogun, Otero, Otero, O’Sullivan, Raffy, Saul, Service, Service, Smallegange, Smith, Smith, Stoddard, Takken, Tatem, Thomas Smith, Tran, van den Driessche, Vazquez-Prokopec, White, Yakob, Yaro   +60 more
core   +1 more source

Spatial and Temporal Heterogeneity in Founding Patterns

Organization Science, 2003
A growing body of literature suggests that populations of organizations are not homogeneous, but instead comprise distinct subentities. Firms are highly dependent on their immediate institutional and competitive environments. The present paper further explores this issue by focusing on the spatial and temporal sources of industry heterogeneity.
Cattani, Gino, Pennings, Johannes M, Wezel, Filipolo Carlo   +2 more
openaire   +4 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source