Results 71 to 80 of about 319,235 (305)
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Quantifying the spatial heterogeneity of geographical flows
Geo-spatial Information ScienceGeographical flows describe the movements and connections of materials, energy, and information among locations and are commonly represented by origin-destination (OD) flows (flows for short).
Hua Shu +8 more
doaj +1 more source
Dynamics of Adaptation in Spatially Heterogeneous Metapopulations
PLoS ONE, 2013 The selection pressure experienced by organisms often varies across the species range. It is hence crucial to characterise the link between environmental spatial heterogeneity and the adaptive dynamics of species or populations. We address this issue by studying the phenotypic evolution of a spatial metapopulation using an adaptive dynamics approach ...
Papaïx, Julien +3 more
openaire +7 more sources
Spatial heterogeneity and habitat configuration overcome habitat composition influences on alpha and beta mammal diversity [PDF]
, 2020 The effects of habitat fragmentation on different taxa and ecosystems are subject to intense debate, and disentangling them is of utmost importance to support conservation and management strategies.
Ribeiro, Milton Cezar +21 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Spatial Heterogeneity in Reaction‐Diffusion Models for Two Competing Species
, 2004 This chapter contains sections titled: Introduction Spatial Heterogeneity within the Habitat Patch Edge Mediated Effects Estimates and Consequences ...
core +2 more sources
Ecological IndicatorsAssessing spatial heterogeneity patterns along human footprint (HF) gradients is important for understanding biodiversity conservation in human-modified landscapes.
Kyoung-Ho Kim +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Agronomy, 2020 Spatial heterogeneity in plant and soil properties plays a key role for biogeochemical cycling, nutrient losses and ecosystem function. Different management practices are expected to induce varying levels of spatial heterogeneity in agroecosystems, but ...
Juliette M. G. Bloor +2 more
doaj +1 more source