Results 61 to 70 of about 3,162,655 (261)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Spatial heterogeneity patterns along the human footprint gradient and their ecological implications: A case study in South Korea

Ecological Indicators
Assessing spatial heterogeneity patterns along human footprint (HF) gradients is important for understanding biodiversity conservation in human-modified landscapes.
Kyoung-Ho Kim, Minkyu Park, Taeho Park, Donghae Baek, Gyobeom Kim, Namjoo Heo, Dong Jun Chun   +6 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Forecasting Regional Labour Market Developments under Spatial Heterogeneity and Spatial Autocorrelation [PDF]

, 2005
Because of heterogeneity across regions, economic policy measures are increasingly targeted at the regional level. As a result, the need for economic forecasts at a sub-national level is rapidly increasing.
Nijkamp, Peter, Nijkamp, P., Longhi, S., Longhi, Simonetta   +3 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Rainfall-Induced landslide susceptibility prediction considering spatial heterogeneity

Earthquake Research Advances
Existing landslide susceptibility prediction methods often fail to fully account for the spatial heterogeneity of environmental factors such as topography, soil, and vegetation, nor do they accurately reflect the impact of extreme rainfall on landslide ...
Xingfu Zhang, Abi Erdi
doaj   +3 more sources

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Imaging Oxygen Distribution in Marine Sediments. The Importance of Bioturbation and Sediment Heterogeneity [PDF]

, 2008
The influence of sediment oxygen heterogeneity, due to bioturbation, on diffusive oxygen flux was investigated. Laboratory experiments were carried out with 3 macrobenthic species presenting different bioturbation behaviour patterns:the polychaetes ...
Poggiale, Jean-Christophe, Cuny, Philippe, Gilbert, Franck, Pischedda, Laura   +3 more
core   +1 more source

Spatial Heterogeneity of Vegetation Structure, Plant N Pools and Soil N Content in Relation to Grassland Management

Agronomy, 2020
Spatial heterogeneity in plant and soil properties plays a key role for biogeochemical cycling, nutrient losses and ecosystem function. Different management practices are expected to induce varying levels of spatial heterogeneity in agroecosystems, but ...
Juliette M. G. Bloor, Antoine Tardif, Julien Pottier   +2 more
doaj   +1 more source