Results 61 to 70 of about 4,411,385 (345)

Spatial genomics enables multi-modal study of clonal heterogeneity in tissues

Nature, 2021
The state and behaviour of a cell can be influenced by both genetic and environmental factors. In particular, tumour progression is determined by underlying genetic aberrations1–4 as well as the makeup of the tumour microenvironment5,6.
Tongtong Zhao, Zachary D. Chiang, Julia W. Morriss, Lindsay M. LaFave, Evan Murray, Isabella S. Del Priore, K. Meli, C. Lareau, Naeem M. Nadaf, Jilong Li, Andrew S. Earl, Evan Z. Macosko, T. Jacks, Jason D. Buenrostro, Fei Chen   +14 more
semanticscholar   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke, Christian Thomas, Michael C. Frühwald, Pascal D. Johann, Martin Hasselblatt   +4 more
wiley   +1 more source

On evolutionary spatial heterogeneous games [PDF]

Physica A: Statistical Mechanics and its Applications, 2008
How coperation between self-interested individuals evolve is a crucial problem, both in biology and in social sciences, that is far from being well understood. Evolutionary game theory is a useful approach to this issue. The simplest model to take into account the spatial dimension in evolutionary games is in terms of cellular automata with just a one ...
openaire   +2 more sources

Intracounty modeling of COVID-19 infection with human mobility: Assessing spatial heterogeneity with business traffic, age, and race

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance A human mobility flow-augmented stochastic susceptible–exposed–infectious–removed–style epidemic modeling framework is developed, which combines with data assimilation and machine learning to reconstruct the historical growth trajectories of
X. Hou, Song Gao, Qin Li, Yuhao Kang, Nan Chen, Kaiping Chen, Jinmeng Rao, J. Ellenberg, J. Patz   +8 more
semanticscholar   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The Effect Of Omitted Spatial Effects And Social Dependence In The Modelling Of Household Expenditure For Fruits And Vegetables [PDF]

, 2014
We find the omitted elements of the external environment affect negatively the estimates for other spatial (social) effect parameters. Especially, we notice the overestimation of the random effect variance when the social dependence is omitted and the ...
Dong, Guanpeng, Harris, Richard, Łaszkiewicz, Edyta   +2 more
core   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Global Production Increased by Spatial Heterogeneity in a Population Dynamics Model [PDF]

, 2005
Spatial and temporal heterogeneity are often described as important factors having a strong impact on biodiversity. The effect of heterogeneity is in most cases analyzed by the response of biotic interactions such as competition of predation. It may also
B.J. Cardinale, B.W. Kooi, C. Bernstein, C. Manté, D. Nérini, F. Gilbert, I. Hanski, J. Huissman, J.-C. Poggiale, J.C. Poggiale, J.C. Poggiale, K. Sakamoto, L. Sanz, L.S. Luckinbill, M. Scheffer, N. Berglund, N. Fenichel, P. Auger, P. Auger, P. Auger, P. Auger, R. Arditi, R. Arditi, R. Bravo de la Parra, S.A. Levin, S.W. Pacala, V. Andersen, Y. Iwasa, Y. Iwasa   +28 more
core   +4 more sources

SPATIAL HETEROGENEITY AND THE WAGE CURVE REVISITED* [PDF]

Journal of Regional Science, 2006
ABSTRACTMost “wage curve” studies ignore the geography of local labor markets. However, when a local labor market is in close proximity of other labor markets, a local shock that increases unemployment may not lead to lower pay rates if employers fear outward migration of their workers.
Longhi, Simonetta, Nijkamp, Peter, Poot, Jacques   +2 more
openaire   +6 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source