Results 61 to 70 of about 267,471 (263)

Quantifying the spatial heterogeneity of geographical flows

Geo-spatial Information Science
Geographical flows describe the movements and connections of materials, energy, and information among locations and are commonly represented by origin-destination (OD) flows (flows for short).
Hua Shu, Tao Pei, Ci Song, Sihui Guo, Jie Chen, Yaxi Liu, Xi Wang, Xiao Chen, Chenghu Zhou   +8 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Spatial heterogeneity patterns along the human footprint gradient and their ecological implications: A case study in South Korea

Ecological Indicators
Assessing spatial heterogeneity patterns along human footprint (HF) gradients is important for understanding biodiversity conservation in human-modified landscapes.
Kyoung-Ho Kim, Minkyu Park, Taeho Park, Donghae Baek, Gyobeom Kim, Namjoo Heo, Dong Jun Chun   +6 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Determination of intertidal macroalgae community patterns using the power law model.

PLoS ONE, 2022
The spatial heterogeneity of macroalgae in intertidal zones affects the stability of marine ecosystem communities, contributes to the maintenance of coastal biodiversity, and has an essential role in ecosystem and habitat maintenance.
Xunmeng Li, Jianqu Chen, Jun Li, Kai Wang, Zhenhua Wang, Shouyu Zhang   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Spatial Heterogeneity of Vegetation Structure, Plant N Pools and Soil N Content in Relation to Grassland Management

Agronomy, 2020
Spatial heterogeneity in plant and soil properties plays a key role for biogeochemical cycling, nutrient losses and ecosystem function. Different management practices are expected to induce varying levels of spatial heterogeneity in agroecosystems, but ...
Juliette M. G. Bloor, Antoine Tardif, Julien Pottier   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source