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SOTIP is a versatile method for microenvironment modeling with spatial omics data
Nature Communications, 2022 Methods that analyse heterogeneity and compare tissue microenvironments using spatial omics data are challenging to develop. Here, the authors present SOTIP, a method that can perform spatial heterogeneity, spatial domain, and differential ...
Zhiyuan Yuan +6 more
doaj +1 more source
Ecological Indicators, 2020 Arid grassland ecosystems undergo degradation because of increasing environmental and human pressures. Degraded grasslands show vegetation cover reduction and soil-patch development, leading to grassland fragmentation and changes in spatial heterogeneity.
Chengxiu Li +4 more
semanticscholar +1 more source
Spatial Heterogeneity in the Tumor Microenvironment [PDF]
Cold Spring Harbor Perspectives in Medicine, 2016 Recent developments in studies of tumor heterogeneity have provoked new thoughts on cancer management. There is a desperate need to understand influence of the tumor microenvironment on cancer development and evolution. Applying principles and quantitative methods from ecology can suggest novel solutions to fulfil this need.
openaire +2 more sources
npj Precision OncologyThe consensus molecular subtypes (CMS) of colorectal cancer (CRC) is the most widely-used gene expression-based classification and has contributed to a better understanding of disease heterogeneity and prognosis.
Alberto Valdeolivas +22 more
semanticscholar +1 more source
Spatial oxygen heterogeneity in a Hediste diversicolor irrigated burrow [PDF]
, 2011 The heterogeneity of oxygen distribution in a Hediste diversicolor burrow environment was investigated in a laboratory experiment using a 6-mm thick tank equipped with oxygen planar optodes. The twodimensional oxygen distribution in a complete burrow was
Cuny, Philippe +4 more
core +5 more sources
Nature Communications, 2021 Metastatic prostate cancer (mPC) comprises a spectrum of diverse phenotypes. However, the extent of inter- and intra-tumor heterogeneity is not established.
L. Brady +14 more
semanticscholar +1 more source
Genome-scale investigation of olfactory system spatial heterogeneity. [PDF]
PLoS ONE, 2017 The early olfactory system is organized in parallel, with numerous, specialized subsystems established by the modular and topographic projections of sensory inputs.
Torben Noto +2 more
doaj +1 more source
A multi-modal data resource for investigating topographic heterogeneity in patient-derived xenograft tumors. [PDF]
, 2019 Patient-derived xenografts (PDXs) are an essential pre-clinical resource for investigating tumor biology. However, cellular heterogeneity within and across PDX tumors can strongly impact the interpretation of PDX studies. Here, we generated a multi-modal,
Altschuler, Steven J +7 more
core
Initiation and dynamics of a spiral wave around an ionic heterogeneity in a model for human cardiac tissue [PDF]
, 2013 In relation to cardiac arrhythmias, heterogeneity of cardiac tissue is one of the most important factors underlying the onset of spiral waves and determining their type.
Dawyndt, Peter +2 more
core +2 more sources
Cell Host and Microbe, 2020 The ecological dynamics underlying the coexistence between antagonistic populations of bacteria and their viruses, bacteriophages (phages), in the mammalian gut microbiota remain poorly understood.
Marta Lourenço +9 more
semanticscholar +1 more source