Results 51 to 60 of about 3,162,655 (261)
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
The effects of variable spatial aggregation on lymphatic filariasis transmission
Parasites & VectorsBackground Elimination of lymphatic filariasis (LF) is a World Health Organization goal, with several countries at or near prevalence thresholds.
Callum Shaw, Angus McLure, Kathryn Glass
doaj +1 more source
SOTIP is a versatile method for microenvironment modeling with spatial omics data
Nature Communications, 2022 Methods that analyse heterogeneity and compare tissue microenvironments using spatial omics data are challenging to develop. Here, the authors present SOTIP, a method that can perform spatial heterogeneity, spatial domain, and differential ...
Zhiyuan Yuan +6 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Spatial models for context-aware indoor navigation systems: A survey [PDF]
, 2012 This paper surveys indoor spatial models developed for research fields ranging from mobile robot mapping, to indoor location-based services (LBS), and most recently to context-aware navigation services applied to indoor environments.
Christophe Claramunt +6 more
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
3D-SHI index for quantifying 3D spatial heterogeneity in big Earth data
International Journal of Digital EarthInvestigating spatial heterogeneity is a crucial aspect of spatial analysis. Existing studies have primarily focused on measuring 2D geographic distribution, which cannot be directly applied to extensive 3D big earth datasets.
Peijie Sun +3 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Quantifying the spatial heterogeneity of geographical flows
Geo-spatial Information ScienceGeographical flows describe the movements and connections of materials, energy, and information among locations and are commonly represented by origin-destination (OD) flows (flows for short).
Hua Shu +8 more
doaj +1 more source