Results 101 to 110 of about 3,162,655 (261)
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Changing determinants of low fertility and diffusion: a spatial analysis for Italy
, 2014 Italy is a case study in lowest-low fertility. Its internal heterogeneity is substantial and changes over time. Historically, the South had higher fertility, but in recent years it the North has become the area with the highest fertility.
Billari, Francesco, Vitali, Agnese
core +2 more sources
Does Context Matter for the Relationship between Deprivation and All-Cause Mortality? The West vs. the Rest of Scotland [PDF]
One of the assumptions that is often made in modeling the relationship between deprivation and mortality is that this relationship will remain the same across space.
Jeremy S. Walker +2 more
core +2 more sources
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Spatial dependence and heterogeneity in patterns of urban deprivation [PDF]
Developments in the provision and quality of digital data are creating possibilities for finer resolution spatial and temporal measurement of the properties of socio-economic systems. We suggest that the ?lifestyles?
Carolina Tobón, Paul Longley
core
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Overlapping jurisdictions and demand for local public services: does spatial heterogeneity matter? [PDF]
This paper aims to test the existence of vertical interactions in terms of public spending between overlapping local jurisdictions in France using a data set of 110 French municipalities and their corresponding departments in 2001 and 2005.
Matthieu Leprince +2 more
core
"Euclidean Revealed Preferences: Testing the Spatial Voting Model" [PDF]
In the spatial model of voting, voters choose the candidate closest to them in the ideological space. Recent work by (Degan and Merlo 2009) shows that it is falsifiable on the basis of individual voting data in multiple elections.
Marc Henry, Ismael Mourifie
core +2 more sources