Results 101 to 110 of about 319,235 (305)
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
Spatial clustering of measles vaccination coverage among children in sub-Saharan Africa
BMC Public Health, 2017 Background During the past two decades, vaccination programs have greatly reduced global morbidity and mortality due to measles, but recently this progress has stalled.
Tenley K. Brownwright +2 more
doaj +1 more source
Ecological Models, Permanence and Spatial Heterogeneity
Rocky Mountain Journal of Mathematics, 1996 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Cantrell, R.S., Cosner, C., Hutson, V.
openaire +2 more sources
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
BMC Medical Research Methodology, 2019 Background In the context of environmentally influenced communicable diseases, proximity to environmental sources results in spatial heterogeneity of risk, which is sometimes difficult to measure in the field.
Abdoulaye Guindo +10 more
doaj +1 more source
From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care
Molecular Oncology, EarlyView.Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Spatial heterogeneity in the urban household living conditions: A-GIS-based spatial analysis
Annals of GISThe unplanned urban expansion and extreme population pressure have caused several bottlenecks for city dwellers, which have been reflected in the form of inter-urban spatial inequality in living conditions at the household level.
Subham Roy +3 more
doaj +1 more source
Self-employment in Brazil and its determinants: a spatial analysis [PDF]
In this paper, we intend to identify some factors underlying the different rates of participation of self-employed workers in Brazilian municipalities. In contrast with previous analysis, our study is sensitive to the spatial dimension of self-employment
Flavia Chein +2 more
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