Results 81 to 90 of about 9,427,830 (306)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Post-Training Sleep Modulates Topographical Relearning-Dependent Resting State Activity

Brain Sciences, 2021
Continuation of experience-dependent neural activity during offline sleep and wakefulness episodes is a critical component of memory consolidation. Using functional magnetic resonance imaging (fMRI), offline consolidation effects have been evidenced ...
Michele Deantoni, Thomas Villemonteix, Evelyne Balteau, Christina Schmidt, Philippe Peigneux   +4 more
doaj   +1 more source

Spatial learning and lateralization in lizards

Biology Letters
Abstract Spatial memory is a fundamental cognitive process that allows animals to navigate and interact with their environment effectively. While extensively studied in mammals and birds, the mechanisms underlying spatial cognition in reptiles remain less understood. In this study, we investigated spatial learning and the influence of
Daniele Pellitteri-Rosa, Birgit Szabo, Andrea Gazzola   +2 more
openaire   +2 more sources

HyperNets and Their Application to Learning Spatial Transformations [PDF]

, 2018
In this paper we propose a conceptual framework for higher-order artificial neural networks. The idea of higher-order networks arises naturally when a model is required to learn some group of transformations, every element of which is well-approximated by a traditional feedforward network. Thus the group as a whole can be represented as a hyper network.
Alexey Potapov, Oleg Shcherbakov, Innokentii Zhdanov, Sergey Rodionov, Nikolai Skorobogatko   +4 more
openaire   +4 more sources

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Gene Network Construction from Microarray Data Identifies a Key Network Module and Several Candidate Hub Genes in Age-Associated Spatial Learning Impairment

Frontiers in Systems Neuroscience, 2017
As humans age many suffer from a decrease in normal brain functions including spatial learning impairments. This study aimed to better understand the molecular mechanisms in age-associated spatial learning impairment (ASLI).
Raihan Uddin, Shiva M. Singh
doaj   +1 more source

Perceptual learning with spatial uncertainties

Vision Research, 2006
In perceptual learning, stimuli are usually assumed to be presented to a constant retinal location during training. However, due to tremor, drift, and microsaccades of the eyes, the same stimulus covers different retinal positions on sequential trials.
Otto, Thomas U., Herzog, Michael H., Fahle, Manfred, Zhaoping, Li   +3 more
openaire   +4 more sources

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source