Results 81 to 90 of about 8,739,015 (304)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

The Use Of Cabri 3D Software As Virtual Manipulation Tool In 3-Dimension Geometry Learning To Improve Junior High School Students’ Spatial Ability [PDF]

, 2011
This study is aimed to know students’ spatial ability who work under 3-dimension learning use Cabri 3D software at Junior High School in Bandung.
Toto , Subroto
core  

Perceptual learning with spatial uncertainties

Vision Research, 2006
In perceptual learning, stimuli are usually assumed to be presented to a constant retinal location during training. However, due to tremor, drift, and microsaccades of the eyes, the same stimulus covers different retinal positions on sequential trials.
Otto, Thomas U., Herzog, Michael H., Fahle, Manfred, Zhaoping, Li   +3 more
openaire   +4 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Fluoxetine restores spatial learning but not accelerated forgetting in mesial temporal lobe epilepsy

, 2012
Learning and memory dysfunction is the most common neuropsychological effect of mesial temporal lobe epilepsy, and because the underlying neurobiology is poorly understood, there are no pharmacological strategies to help restore memory function in these ...
Shtaya, Anan, Taylor, Matthew, Hamilton, Derek A., Gray, William Peter, Barkas, Lisa, Redhead, Edward, Gray, William P.   +6 more
core   +1 more source

Vision and strategy making: Teaching spatial planning in design education on a situated learning environment

, 2022
This chapter introduces the pedagogical approach of guiding vision and strategy making in university design studios. This is a unique way of teaching spatial planning in design education, bridging research, planning, and design.
Qu, L. (author), Sepulveda Carmona, D.A. (author), Stead, D. (author), Dabrowski, M.M. (author)   +3 more
core   +1 more source

Postural Control While Walking Interferes With Spatial Learning in Older Adults Navigating in a Real Environment

Frontiers in Aging Neuroscience, 2020
Cognitive demands for postural control increase with aging and cognitive-motor interference (CMI) exists for a number of walking situations, especially with visuo-spatial cognitive tasks. Such interference also influences spatial learning abilities among
Catherine Persephone Agathos, Stephen Ramanoël, Stephen Ramanoël, Marcia Bécu, Delphine Bernardin, Delphine Bernardin, Christophe Habas, Angelo Arleo   +7 more
doaj   +1 more source

Spatial learning and lateralization in lizards

Biology Letters
Abstract Spatial memory is a fundamental cognitive process that allows animals to navigate and interact with their environment effectively. While extensively studied in mammals and birds, the mechanisms underlying spatial cognition in reptiles remain less understood. In this study, we investigated spatial learning and the influence of
Daniele Pellitteri-Rosa, Birgit Szabo, Andrea Gazzola   +2 more
openaire   +2 more sources

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source