Results 71 to 80 of about 8,739,015 (304)

Prospecting the protein design landscape

open access: yesFEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona   +4 more
wiley   +1 more source

Shortcutting from self-motion signals reveals a cognitive map in mice

open access: yeseLife
Animals navigate by learning the spatial layout of their environment. We investigated spatial learning of mice in an open maze where food was hidden in one of a hundred holes.
Jiayun Xu   +4 more
doaj   +1 more source

Young adult born neurons enhance hippocampal dependent performance via influences on bilateral networks

open access: yeseLife, 2016
Adult neurogenesis supports performance in many hippocampal dependent tasks. Considering the small number of adult-born neurons generated at any given time, it is surprising that this sparse population of cells can substantially influence behavior ...
Jia-Min Zhuo   +10 more
doaj   +1 more source

HyperNets and Their Application to Learning Spatial Transformations [PDF]

open access: yes, 2018
In this paper we propose a conceptual framework for higher-order artificial neural networks. The idea of higher-order networks arises naturally when a model is required to learn some group of transformations, every element of which is well-approximated by a traditional feedforward network. Thus the group as a whole can be represented as a hyper network.
Alexey Potapov   +4 more
openaire   +4 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

The role of expertise, semantics, and learning in spatial memory [PDF]

open access: yes, 2012
This research investigates the mechanisms that underpin object location memory. It approaches this endeavour by examining a recently reported phenomenon of spatial memory, that of exclusivity.
Dunn, TJ
core  

Beyond alienation: spatial implications of teaching and learning academic writing [PDF]

open access: yes, 2018
Despite existing work on the situated and sometimes alienating nature of academic writing practices, the implications of the specifically spatial nature of these practices continue to pose questions for teaching and learning in higher education.
Beighton, C.
core   +1 more source

Higher Education: Increased and Equitable Access to Quality Learning Opportunities

open access: yes, 2019
Given that many developing countries seek to increase participation in Higher Education (HE), COL will work with Ministries of Education and HE Institutions to support capacity building including the development and implementation of Open and Distance ...
Commonwealth of Learning
core   +1 more source

Prefrontal serotonin depletion delays reversal learning and increases theta synchronization of the infralimbic-prelimbic-orbitofrontal prefrontal cortex circuit

open access: yesFrontiers in Pharmacology
IntroductionPrefrontal serotonin plays a role in the expression of flexible behavior during reversal learning tasks as its depletion delays reversal learning.
Yoana Estrada-Reyes   +4 more
doaj   +1 more source

Spatial Metaphor Facilitates Word Learning

open access: yesChild Development, 2020
Abstract Why are spatial metaphors, like the use of “high” to describe a musical pitch, so common? This study tested one hundred and fifty-four 3- to 5-year-old English-learning children on their ability to learn a novel adjective in the domain of space or pitch and to extend this adjective to the untrained dimension.
Ariel Starr   +3 more
openaire   +4 more sources

Home - About - Disclaimer - Privacy