Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Bayesian spatial NBDA for diffusion data with home-base coordinates [PDF]
, 2015 Network-based diffusion analysis (NBDA) is a statistical method that allows the researcher to identify and quantify a social influence on the spread of behaviour through a population.
Laland, Kevin Neville +15 more
core +1 more source
Spatial-Temporal Graph Contrastive Learning for Urban Traffic Flow Forecasting
, 2023 Graph Neural Networks(GNNs) integrating contrastive learning have attracted growing attentions in urban traffic flow forecasting. However, most existing graph contrastive learning works donot perform well in capturing local-global spatial dependencies ...
Jinbao Li (17371109) +2 more
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Age-dependent social learning in a lizard [PDF]
, 2014 Funding: Australian Funding CouncilEvidence of social learning, whereby the actions of an animal facilitate the acquisition of new information by another, is taxonomically biased towards mammals, especially primates, and birds.
Noble, Danial W A +5 more
core +1 more source
Effects of Maternal Separation on Nicotine-Induced Conditioned Place Preference and Later Spatial Learning and Memory Function in Adolescent Male Rats [PDF]
Addiction and Health, 2016 Background: Disturbances in maternal care have been associated with increased risk for drug abuse later in life. However, there has been little investigation of the effects of maternal separation (MS), a model of early life stress, on nicotine dependence,
Fatemeh Delavari +4 more
doaj
Comparative neuroprotective and cognitive effects of human umbilical cord mesenchymal stem cells, secretome, and exosomes in a rat model of pilocarpine-induced epilepsy [PDF]
Veterinary WorldBackground and Aim: Epilepsy is a chronic neurological disorder characterized by recurrent seizures, neuronal degeneration, and cognitive impairment. Current antiepileptic therapies mainly control seizures and do not effectively prevent epileptogenesis ...
Sri Hastuti +4 more
doaj +1 more source
Deep spatial autoencoders for visuomotor learning [PDF]
2016 IEEE International Conference on Robotics and Automation (ICRA), 2016 Published in the International Conference on Robotics and Automation (ICRA)
Chelsea Finn +5 more
openaire +2 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Building a cognitive map through self-motion
eLifeMice can generate a cognitive map of an environment based on self-motion signals when there is a fixed association between their starting point and the location of their goal.
Bharath Krishnan, Noah Cowan
doaj +1 more source