Results 51 to 60 of about 25,082 (249)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Two-dimensional pixel-level addressable mid-infrared metasurface spatial light modulator

Nature Communications
Active metasurfaces enable dynamic control of light for applications in beam steering, pixelated holography, and adaptive optics, but demonstrations of two-dimensional electrically addressable arrays have so far been limited. Here we introduce a scalable
Cosmin-Constantin Popescu, Maarten Robbert Anton Peters, Oleg Maksimov, Harish B. Bhandari, Rashi Sharma, Kathleen A. Richardson, Arka Majumdar, Hyun Jung Kim, Rui Chen, Khoi Phuong Dao, Luigi Ranno, Brian Mills, Dennis M. Calahan, Tian Gu, Juejun Hu   +14 more
doaj   +1 more source

High resolution multispectral spatial light modulators based on tunable Fabry-Perot nanocavities

Light: Science & Applications, 2022
A spatial light modulator is demonstrated based on Fabry-Perot nanocavity resonances, enabling micrometer-sized pixels and efficient full phase control at multiple wavelengths simultaneously, across the visible spectrum (including RGB colors).
Shampy Mansha, Parikshit Moitra, Xuewu Xu, Tobias W. W. Mass, Rasna Maruthiyodan Veetil, Xinan Liang, Shi-Qiang Li, Ramón Paniagua-Domínguez, Arseniy I. Kuznetsov   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Patterned Rydberg excitation and ionization with a spatial light modulator

New Journal of Physics, 2015
We demonstrate the ability to excite atoms at well-defined, programmable locations in a magneto-optical trap, either to the continuum (ionization), or to a Rydberg state.
R M W van Bijnen, C Ravensbergen, D J Bakker, G J Dijk, S J J M F Kokkelmans, E J D Vredenbregt   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A practical guide to digital micro-mirror devices (DMDs) for wavefront shaping

JPhys Photonics
Digital micromirror devices have gained popularity in wavefront shaping, offering a high frame rate alternative to liquid crystal spatial light modulators.
Sébastien M Popoff, Louis Malosse, Rodrigo Gutiérrez-Cuevas, Yaron Bromberg, Jean Commère, Marie Glanc, Raphaël Galicher, Maxime W Matthès   +7 more
doaj   +1 more source