Results 121 to 130 of about 365,427 (304)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Laguerre-Gaussian mode sorters of high spatial mode count

, 2020
We discuss the extension of Laguerre-Gaussian (LG) mode sorters to higher spatial mode counts. LG mode sorters based on multi-plane light conversion were recently demonstrated.
Neilson, David T., Chen, Haoshuo, Fontaine, Nicolas K., Nicolas K. Fontaine, Roland Ryf, David T. Neilson, Carpenter, Joel, Joel Carpenter, Ryf, Roland, Kwangwoong Kim, Kim, Kwangwoong, Haoshuo Chen   +11 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Spatial Mode Selection by the Phase Modulation of Subwavelength Plasmonic Grating

, 2010
The extraordinary transmission of the subwavelength gold grating has been investigated by the rigorous coupled-wave analysis and verified by the metal-insulator-metal plasmonic waveguide method.
Song, GF, Chinese Acad Sci, Inst Semicond, POB 912, Beijing 100083, Peoples R China. sgf@semi.ac.cn, Song GF (Song Guofeng), Zhang J (Zhang Jing), Cai LK (Cai Likang), Wei X (Wei Xin), Wang Q (Wang Qing), Bai WL (Bai Wenli)   +6 more
core  

Remote transport of high-dimensional orbital angular momentum states and ghost images via spatial-mode-engineered frequency conversion. [PDF]

Nat Commun, 2023
Qiu X, Guo H, Chen L.
europepmc   +1 more source

Spectroscopy with spatial modes of light

, 2021
En aquest projecte volem estudiar l'aplicació coneguda com a espectroscòpia espacial, una tècnica d'imatge exploratòria que consisteix en utilitzar els modes espacials de la llum per a obtenir informació sobre un objecte. Aquesta informació es dedueix mitjançant la descomposició en modes.
openaire   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

High-fidelity spatial mode transmission through a 1-km-long multimode fiber via vectorial time reversal. [PDF]

Nat Commun, 2021
Zhou Y, Braverman B, Fyffe A, Zhang R, Zhao J, Willner AE, Shi Z, Boyd RW.   +7 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source